Puzzles Feed

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Puzzle
Expired: 08/01/17 23:00:00
Top Group: Beta Folders
Top Player: reefyrob
Top Score: 9,543
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 07/28/17 23:00:00
1 comment
Top Group: Beta Folders
Top Player: smilingone
Top Score: 10,495
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. The Core Existence filter has been escalated so that 35% of residues need to be buried in the protein core. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 07/27/17 23:00:00
Top Group: Contenders
Top Player: gitwut
Top Score: 9,996
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein shuttles lipids between cell membranes in the rice plant. The protein contains eight cysteines that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/31/17 23:00:00
Top Group: BI 340 Lab
Top Player: sciolizer
Top Score: 8,657
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expired: 07/25/17 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,685
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 07/21/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: eusair
Top Score: 10,609
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The Core Existence filter has been escalated so that 40% of residues need to be buried in the protein core. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/24/17 23:00:00
Top Group: Void Crushers
Top Player: Madde
Top Score: 8,763
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expired: 07/20/17 18:00:00
Top Group: Beta Folders
Top Player: smilingone
Top Score: 9,313
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein allows bacteria to metabolize ethanolamine and use it in constructing cell walls and cell membranes. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 07/18/17 23:00:00
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 9,818
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 07/14/17 23:00:00
3 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 10,208
Categories: Overall, Prediction
This puzzle challenges players to design a single-chain protein with 65-75 residues. The Core Existence filter has been escalated so that 35% of residues need to be buried in the protein core. The starting structure has 65 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons