Puzzles Feed

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Puzzle
Expired: 08/03/19 23:00:00
1 comment
Top Group: Void Crushers
Top Player: Timo van der Laan
Top Score: 10,789
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 08/05/19 18:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 15,628
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is able to absorb light and use the energy to transfer chloride ions across the cell membrane. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 07/30/19 23:00:00
3 comments
Top Group: Contenders
Top Player: georg137
Top Score: 11,227
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 07/31/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 18,582
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 07/29/19 18:00:00
1 comment
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 11,749
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein was designed by the Baker Lab in 2003, and has a topology unlike any natural protein yet discovered. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 07/26/19 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 12,894
Categories: Design, Overall
Design a protein for electron transfer! See the blog for more details!
Puzzle
Expired: 07/24/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 19,868
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 07/22/19 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 12,789
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein binds fatty acids in intestinal cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 07/19/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,449
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 07/17/19 23:00:00
Top Group: Anthropic Dreams
Top Player: guineapig
Top Score: 10,291
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons