Puzzles Feed

Closed

Puzzle
Expired: 12/04/19 18:00:00
Top Group: Beta Folders
Top Player: Aubade01
Top Score: 10,835
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein, which inhibits muscle contraction in the absence of calcium ions, changes conformation in the presence of calcium to allow muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 12/02/19 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 19,990
Categories: Design, Overall, Symmetry
H-bond Networks are back! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks.
Puzzle
Expired: 11/28/19 23:00:00
4 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 8,800
Categories: Design, Overall
This puzzle introduces a new secondary structure, the poly-proline helix! The starting structure is a small 38 residue protein with a frozen helix and designable residues on either end. Players should fold the starting structure to create a compact globular protein that incorporates this new type of secondary structure. Note that the backbone of the poly-proline helix has bondable oxygen atoms. If any of these oxygens are buried in the protein core, they will need to make hydrogen bonds! See the blog for more information!
Puzzle
Expired: 11/27/19 18:00:00
1 comment
Top Group: Void Crushers
Top Player: Timo van der Laan
Top Score: 10,346
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/25/19 23:00:00
6 comments
Top Group: Contenders
Top Player: georg137
Top Score: 24,228
Categories: Design, Overall, Symmetry
H-bond Networks are back! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks. There a few other objectives in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 11/21/19 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 13,736
Categories: Overall, Prediction, Symmetry
Note: This puzzle replaces Puzzle 1760, which was mistakenly posted with the wrong sequence.
Puzzle
Expired: 11/21/19 23:00:00
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 13,645
Categories:
Note: This puzzle was mistakenly posted with the wrong sequence, and has been closed and reposted as Puzzle 1760b.
Puzzle
Expired: 11/20/19 18:00:00
2 comments
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 10,454
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This pheromone protein is secreted by the protist E. raikovi to initiate conjugation, the exchange of genetic material between two cells. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/18/19 23:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 21,231
Categories: Design, Overall, Symmetry
H-bond Networks are back! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks. There a few other objectives in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 11/14/19 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,024
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons