Puzzles Feed

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Puzzle
Expired: 10/31/19 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,231
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 10/30/19 18:00:00
3 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,176
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This eelpout protein binds nucleated ice crystals to inhibit their growth. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 10/28/19 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 23,547
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 10/23/19 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 11,200
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 10/19/19 23:00:00
1 comment
Top Group: Go Science
Top Player: Hollinas
Top Score: 11,354
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 10/23/19 18:00:00
3 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,735
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small peptide was discovered in platypus venom-a rare instance of mammalian-produced venom, although this peptide appears similar to more widespread antimicrobials. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 10/21/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 20,549
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 10/15/19 23:00:00
1 comment
Top Group: Go Science
Top Player: dcrwheeler
Top Score: 11,052
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 10/16/19 18:00:00
1 comment
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 10,709
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This domain is a component of a large glycoprotein in humans that has been linked to autosomal dominant polycystic kidney disease. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 10/11/19 23:00:00
1 comment
Top Group: Go Science
Top Player: Hollinas
Top Score: 11,343
Categories: Design, Overall
Design a protein that binds IL-7R!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons