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Puzzle
Expired: 12/26/19 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 11,134
Categories: Design, Overall
This is the fourth puzzle in the poly-proline helix design series! The starting structure is identical to the one in round 3, with an 80 residue protein and an 8 residue helix. The backbone will be frozen to maintain the poly-proline helix secondary structure, but we are now giving you free rein to design the residues on the helix. We want to see how you will satisfy the exposed oxygens on the helix backbone, because proteins that satisfy all internal oxygens with hydrogen bonds have the best chance of folding in the lab.
Puzzle
Expired: 12/25/19 18:00:00
1 comment
Top Group: Go Science
Top Player: silent gene
Top Score: 9,833
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, which is released by the sea anemone A. xanthogrammica, disrupts normal contraction of cardiac muscle in potential predators, and furthermore serves as a pheromone to signal danger to nearby anemones. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 12/20/19 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 22,885
Categories: Design, Overall, Symmetry
H-bond Networks are back! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks.
Puzzle
Expired: 12/19/19 23:00:00
7 comments
Top Group: Go Science
Top Player: silent gene
Top Score: 11,695
Categories: Design, Overall
This is the third puzzle in our poly-proline helix design series! This is an 80 residue protein with a shorter 8-residue long frozen poly-proline helix, and designable residues on either side. Just like in Rounds 1 and 2, it will be necessary to satisfy the exposed oxygens on the helix backbone to ensure that the protein stays folded! Globular structures with a hydrophobic core will have the best chance of folding in the real world.
Puzzle
Expired: 12/18/19 18:00:00
1 comment
Top Group: Go Science
Top Player: silent gene
Top Score: 10,408
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Chinese cobra N. atra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 12/13/19 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 14,279
Categories: Electron Density, Overall, Prediction
Fold a kinesin protein into an electron density map! This is a follow-up to Puzzle 1767, now starting with the crystallographer's structure! Players may also load in their solutions from Puzzle 1767. Note that this puzzle will only be up for 5 days, and will expire on December 13.
Puzzle
Expired: 12/12/19 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 11,008
Categories: Design, Overall
This is the second puzzle in our poly-proline helix design series! This is an 80 residue protein with a 12-residue long frozen poly-proline helix, and designable residues on either side. Just like in Round 1, it will be necessary to satisfy the exposed oxygens on the helix backbone to ensure that the protein stays folded! Globular structures with a hydrophobic core will have the best chance of folding in the real world.
Puzzle
Expired: 12/11/19 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,428
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Mozambique spitting cobra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues, which oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 12/09/19 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 14,270
Categories: Electron Density, Overall, Prediction
Fold a kinesin protein into an electron density map! We are giving you a monomer unit of the crystal structure 6IGN, which represents the coiled-coil stalk portion of a kinesin protein. Kinesins are motor proteins that transport cargo within the cell, by "walking" along the cellular cytoskeleton. This particular crystal structure of has a poor R-free value, meaning that some of the x-ray diffraction data is poorly explained by the crystallographer's structure. We are curious whether Foldit players can build a better structure into the electron density map!
Puzzle
Expired: 12/05/19 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 29,041
Categories: Design, Overall, Symmetry
Redesign a TIM barrel protein with symmetry! We're looking for Foldit players' help in redesigning a well-behaved monomeric protein, so that it self-assembles into a trimer with C3 symmetry. The starting structure is a large (184 residue) protein previously designed in the Baker Lab. Players should bring the three symmetric units into contact, and redesign the interface between units. We expect the monomer unit may need to change shape slightly to make a good interface, so the backbone is flexible and all positions can be redesigned. In nature, proteins with this kind of fold (called a TIM barrel) are frequently found as symmetric complexes. We'd like to see if we can turn this designed TIM barrel into a symmetric complex, but this is a difficult problem for our computer programs in the Baker Lab. We think Foldit players can help!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons