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Puzzle
Expired: 07/24/20 18:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 12,984
Categories: Overall, Prediction
THIS IS A MULTISTART PUZZLE - Click "RESET PUZZLE" to cycle through both starting structures. CASP14 has released another refinement target with 2 different starting structures. They did not reveal the accuracy of either starting model, but we do know that they are both incorrect. Try to explore far enough away from both starting structures, as the highest-scoring folds might be far away from both starts!

Puzzle
Expired: 07/23/20 23:00:00
1 comment
Top Group: Go Science
Top Player: ichwilldiesennamen
Top Score: 12,000
Categories: Design, Overall
Design an anti-inflammatory protein for COVID-19! This puzzle is set up exactly like Round 7, and we'd like players to keep focusing on making closely-packed interfaces with no extra Buried Unsats. If your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the target. (Note that this target protein includes 15 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players will be unable to load solutions from previous puzzles.
Puzzle
Expired: 07/22/20 23:00:00
4 comments
Top Group: Go Science
Top Player: Dhalion
Top Score: 19,049
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle has no H-Bond Network objective, but there is "Core Limit: Complex" objective meant to limit the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 07/17/20 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 12,073
Categories: Overall, Prediction
THIS IS A MULTISTART PUZZLE - Click "RESET PUZZLE" to cycle through both starting structures. CASP14 has released another refinement target with 2 different starting structures. They did not reveal the accuracy of either starting model, but we do know that they are both incorrect. Try to explore far enough away from both starting structures, as the highest-scoring folds might be far away from both starts!

Puzzle
Expired: 07/16/20 23:00:00
1 comment
Top Group: Go Science
Top Player: clark92
Top Score: 14,858
Categories: Design, Overall
Design a binder against coronavirus! We saw some great looking designs in the previous Round 12 puzzle; we want to see even more! This puzzle is set up exactly like Round 12, and we'd like players to keep focusing on making closely packed interfaces with no extra BUNS. If your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the coronavirus target. (Note that this target protein includes 8 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players may not load solutions from previous puzzles.
Puzzle
Expired: 07/15/20 23:00:00
3 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 18,486
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 07/10/20 18:00:00
2 comments
Top Group: Go Science
Top Player: NinjaGreg
Top Score: 11,867
Categories: Overall, Prediction
THIS IS A MULTISTART PUZZLE - Click "RESET PUZZLE" to cycle through both starting structures.
Puzzle
Expired: 07/09/20 23:00:00
8 comments
Top Group: Go Science
Top Player: Dhalion
Top Score: 11,918
Categories: Design, Overall
Design an anti-inflammatory protein for COVID-19! The Buried Unsats Objective has been reactivated and it will incur a 60 pt penalty for each BUNS atom. If your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the target. (Note that this target protein includes 15 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players will be unable to load solutions from previous puzzles.
Puzzle
Expired: 07/08/20 23:00:00
3 comments
Top Group: Go Science
Top Player: NinjaGreg
Top Score: 21,250
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, which penalizes buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 07/03/20 18:00:00
Top Group: Go Science
Top Player: joshmiller
Top Score: 11,568
Categories: Overall, Prediction
CASP14 has released this refinement target with this additional explanation: "Hard refinement target. Starting model's GDT_HA=28." This means that less than one third of this starting model matches the unreleased native structure. Try exploring as far as you can from the starting structure!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons