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Puzzle
Expired: 08/17/17 18:00:00
Top Group: Contenders
Top Player: Glen B
Top Score: 9,824
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein, from the venom of the saw-scaled viper, interferes with the cellular adhesion machinery that allows blood clotting. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/21/17 23:00:00
Top Group: Anthropic Dreams
Top Player: dimension9
Top Score: 8,949
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expired: 08/16/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,608
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 08/11/17 23:00:00
1 comment
Top Group: Beta Folders
Top Player: smilingone
Top Score: 10,241
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 65 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/14/17 23:00:00
Top Group: Go Science
Top Player: DodoBird
Top Score: 15,060
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expired: 08/09/17 23:00:00
24 comments
Top Group: Anthropic Dreams
Top Player: eusair
Top Score: 9,507
Categories: Overall, Prediction
Focus on your early game as we revisit puzzle 1381: Unsolved De-novo Freestyle 105. In this Sketchbook puzzle, you have 250 moves at your disposal. Once you use them up, you can reset and try something else!
Puzzle
Expired: 08/08/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,932
Categories: Design, Overall
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 08/04/17 23:00:00
3 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,972
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 95-120 residues. The Core Existence filter has been escalated so that 40% of residues need to be buried in the protein core. The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/03/17 18:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 8,926
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein comes from the bacteria Escherichia coli, but its function is still unknown! We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/07/17 23:00:00
Top Group: Anthropic Dreams
Top Player: dimension9
Top Score: 8,985
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons