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Puzzle
Expired: 06/10/19 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,527
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is part of a metabolic pathway used by bacteria to harvest energy from sugars. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/07/19 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 24,744
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 06/05/19 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,657
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. Ubiquitin is a well-known protein that helps to regulate the natural turnover of proteins in the cell, and this starting structure is a model of the protein produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/03/19 23:00:00
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 10,376
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 05/31/19 23:00:00
2 comments
Top Group: Gargleblasters
Top Player: johnmitch
Top Score: 14,935
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 05/29/19 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,904
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a throwback puzzle to the early days of Foldit. This protein helps to regulate the human immune response, and the starting structure is a Rosetta model. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/27/19 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 14,382
Categories: Overall, Prediction, Symmetry
This is a follow-up to Puzzle 1673: De-novo Freestyle 152, now with C2 symmetry. This protein was originally designed by a Foldit player as a symmetric dimer. In Puzzle 1673, we challenged the Foldit community to try and predict how the design might fold as a single, monomeric chain. Now we want to see if Foldit players can predict how the original protein was designed to fold and bind to itself with C2 symmetry. Players may load in solutions from Puzzle 1673. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 05/23/19 23:00:00
9 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 7,179
Categories: Design, Overall
Help design a protein binder for cancer therapy!
Puzzle
Expired: 05/21/19 18:00:00
4 comments
Top Group: L'Alliance Francophone
Top Player: jobo0502
Top Score: 10,028
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein, from the venom of the saw-scaled viper, interferes with the cellular adhesion machinery that allows blood clotting. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/20/19 23:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 10,167
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons