Puzzles Feed

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Puzzle
Expired: 05/15/20 18:00:00
8 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,115
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of exocytosis, transporting proteins to the cell membrane or extracellular areas. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 05/14/20 23:00:00
11 comments
Top Group: Hold My Beer
Top Player: Steven Pletsch
Top Score: 11,575
Categories: Overall, Prediction
Fold this coronavirus protein! This is one portion of a larger protein encoded in the viral genome of SARS-CoV-2. It is encoded in a region of the genome called NSP2, but the protein's structure and function are still unknown. If we knew how this protein folds, we might be able to figure out its exact function. The puzzle's starting structure shows SS predictions from PSIPRED, and hints which parts of the protein might fold into helices or sheets. Refold this protein to find high-scoring solutions, which will tell us how this protein is most likely to fold!
Puzzle
Expired: 05/13/20 23:00:00
6 comments
Top Group: Gargleblasters
Top Player: Formula350
Top Score: 13,272
Categories: Design, Overall
Design an anti-inflammatory protein for COVID-19! The starting structure is a design by Bruno Kestemont from Puzzle 1824, as featured in our latest video Lab Report #8. Players may work to try and improve the starting structure, but also have the freedom to redesign binder from scratch. The best designs will have lots of helix or sheet structure, with a large core of orange hydrophobics. See our previous blog post for tips about designing a successful binder! Players may not load in solutions from previous puzzles.
Puzzle
Expired: 05/07/20 23:00:00
2 comments
Top Group: Hold My Beer
Top Player: Steven Pletsch
Top Score: 10,106
Categories: Overall, Prediction
Refold the loops in this Aflatoxin Challenge design! This is a followup to Round 15, this time starting with a completely unfolded loop. Previously, Foldit players had redesigned the binding loops of an oxidation enzyme, and testing at the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design. If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!
Puzzle
Expired: 05/08/20 18:00:00
2 comments
Top Group: Go Science
Top Player: Dhalion
Top Score: 11,271
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is produced in the intestines of the African black mamba. The protein contains ten cysteines that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 05/06/20 23:00:00
7 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 14,882
Categories: Design, Overall
Design a binder against coronavirus! This puzzle is similar to Rounds 1 and 2 of our Coronavirus Binder Design challenge. but with tighter limits on the allowed number of segments. The starting structure has 177 segments, and players may use no more than 182 total. See the Foldit blog for tips on making a successful protein binder!
Puzzle
Expired: 04/29/20 23:00:00
5 comments
Top Group: Go Science
Top Player: mirp
Top Score: 12,841
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1828, which had some errors in the protein backbone. Players may load solutions saved in Puzzle 1828.
Puzzle
Expired: 05/01/20 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,885
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is an allergen produced by the white birch tree. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 04/30/20 23:00:00
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 10,160
Categories: Overall, Prediction
Refold the loops in this Aflatoxin Challenge design! This is a followup to Round 14, this time starting with a completely unfolded loop. Previously, Foldit players had redesigned the binding loops of an oxidation enzyme, and testing at the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design. If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!
Puzzle
Expired: 04/29/20 23:00:00
7 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 12,389
Categories:
Note: This puzzle was closed early due to some problems with the protein backbone, and a corrected version was reposted as Puzzle 1828b. Players may load their saved solutions into the reposted puzzle.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons