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Puzzle
Expired: 10/12/17 23:00:00
Top Group: Alpha Rays
Top Player: Ricardo Oliveira
Top Score: 8,673
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expired: 09/01/17 23:00:00
10 comments
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 8,074
Categories: Design, Overall
Redesign the loops of this protein to better bind the ligand! Nicotinamide mononucleotide (NMN) is a small-molecule that makes up part of the small-molecule nicotinamide adenine dinucleotide (NAD), which is sometimes regarded as 'the molecule of youth.' Scientists know that the amount of NAD in our cells declines as we age, and so designing a protein to bind to NMN is the first step towards achieving protein-based biosensors that can detect NMN levels in cells. Such biosensors would help scientists to understand the aging process and could potentially lead to a 'cure' for aging!
Puzzle
Expired: 10/05/17 23:00:00
Top Group: Anthropic Dreams
Top Player: dimension9
Top Score: 8,722
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expired: 08/31/17 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,226
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. Ubiquitin is a well-known protein that helps to regulate the natural turnover of proteins in the cell, and this starting structure is a model of the protein produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/30/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 8,685
Categories: Overall, Prediction
Note: Due to scoreboard instabilities, the deadline for this puzzle has been extended 24 hours, to August 30 at 23:00 UTC.
Puzzle
Expired: 08/25/17 23:00:00
4 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,532
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/24/17 18:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 10,033
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a throwback puzzle to the early days of Foldit. This protein helps to regulate the human immune response, and the starting structure is a Rosetta model. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/28/17 23:00:00
Top Group: Anthropic Dreams
Top Player: Shminky Pinky
Top Score: 10,941
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 08/22/17 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 9,459
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 08/18/17 23:00:00
3 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,702
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons