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This puzzle has been reposted. Please use the new version of this puzzle, 689b. You may load your MANUAL saves into the new puzzle. We apologize for any inconvenience.

This is the sequel to puzzle 675, where you folded two symmetric chains attached to a central catalyst molecule. We've kept the catalyst and the chains identical, but we're moving beyond just folding: it's time to make this catalyst go turbo. It needs protons fed to its inner nitrogen (an H-bond acceptor) to go faster, so we're giving you a large bonus for making an H-bond to this atom. Fair warning: it's a bit crowded in there, so the angle has to be just-right to avoid a clash. This is the atom in the central, bent ring that attaches to the flat outer ring. It looks blue in CPK mode and glows red when "show bondable atoms" and "show bonds (non-protein)" are turned on, under "View". Try to come up with stable folds that reach this atom!

This puzzle has been reposted. Please use the new version of this puzzle, 688b. You may load your MANUAL saves into the new puzzle.

We are giving you a single chain of 76 residues to design. You will need the latest version of the client to play this puzzle There are 4 filters enabled in this puzzle. They are slow to compute, so you may want to check "Disable slow filters" in the behavior tab for when you are manually pulling and running your scripts. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is between 30% and 70%. The "Polar Core" filter that the residues in the core are properly hydrophobic. The "Layer Design" filter looks at the interactions of the residues based on the surface area of the protein. Residues can be either in the core, on the boundary or on the surface of the protein. Depending on the surroundings, the "Layer Design" filter will give you a bonus if your amino acid matches what it was expecting. Press TAB on each residue to find out more about these filters. You will not be able to load in your solutions from 676. Because of issues with the filters in that puzzle, we wanted to get a fresh start with these new filters. If everything goes well, nearing the end of this puzzle we will post a 76 residue symmetric dimer puzzle where you will be able to load your solution from this monomer into the dimer. Keep that in mind when you are designing your monomer.

This currently unsolved short protein does not have any templates that we can use, so we are giving it to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

We are giving you a Foldit prediction by wudoo from Puzzle 671 for you to refine. Only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. For players with fewer than 150 global points.

We are giving you a Foldit prediction by wudoo from Puzzle 671 for you to refine. Only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. For players with fewer than 15 global points.

We are giving you a Foldit prediction by wudoo from Puzzle 671 for you to refine. Only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing.

This is round 2 for Puzzle 680. You will be able to load in your manual saves from 680 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch! NOTE: If you did not manually save a solution in puzzle 680, you can go back to 680, manually save it, and the solution should appear in your manual saves for this puzzle.

We are reposting this 33 residue CASP10 target to try out the new Disulfide Count Score Filter. We are giving you the top-predicted templates from 3 different alignment programs and you can see that they are all very similar. More details about this CASP target are in the puzzle comments.