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Puzzle
Expired: 09/30/19 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,265
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is found in high concentrations in the lens of the eye. Among its other functions, it is responsible for the high refractive index (and resulting optical properties) of the lens. The protein is modeled here in reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/25/19 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Blipperman
Top Score: 11,550
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/25/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 18,999
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/21/19 23:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,278
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/23/19 18:00:00
1 comment
Top Group: Go Science
Top Player: dcrwheeler
Top Score: 10,896
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein domain is a component of the histone protein complex, which packages DNA into compact units called nucleosomes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/17/19 23:00:00
3 comments
Top Group: Go Science
Top Player: Phyx
Top Score: 11,458
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/18/19 23:00:00
1 comment
Top Group: Marvin's bunch
Top Player: dcrwheeler
Top Score: 17,689
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. We've omitted the "Core Exists: Complex" objective to simplify the puzzle, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/13/19 23:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,888
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/16/19 18:00:00
1 comment
Top Group: Marvin's bunch
Top Player: jausmh
Top Score: 10,992
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is another potent neurotoxin produced by scorpions, similar to that found in Puzzle 55. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/09/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,993
Categories: Design, Overall
Design a protein that binds IL-7R!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons