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The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get! For players with fewer than 15 global points.

The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get!

Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by allowing you to redesign & insert up to 6 residues to form additional hydrogen bonds with the sugar. To encourage this, only GUI scripts are allowed, and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You will be able to load in your solutions from the first puzzle and refine them with scripting and sharing. Please read the new puzzle comments for more details. AND PLEASE NOTICE that Valine 32 can be mutated!

We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. This Revisiting Puzzle goes back to November 2011, Nanog Transcription Factor 2: http://fold.it/portal/node/991096. Resetting the puzzle will cycle through 10 Quark server predictions that are also in the Alignment Tool so you can use partial threading.

This is a 70 residue symmetric trimer design puzzle; there will be three symmetric chains to manage. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871 There is only 1 filter enabled in this puzzle. The Residue IE Score monitors all PHY, TYR, and TRP residues are scoring well. Press TAB on each residue to find out exactly what it expects of residues that do not meet the IE (interaction energy) requirements. The score function is slightly different than on previous symmetry puzzles. We're hoping to see if this modification can replace the slow filters that have been previously enabled in other puzzles.

This is Round 2 for Puzzle 689. You will be able to load in your manual saves from 689 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 689, you can go back to 689, manually save it, and the solution should appear in your manual saves for this puzzle.

We are giving you another currently unsolved protein as an extended chain, but this time only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is stuck in a local minimum, can you use the Foldit tools you just learned to improve the model and match the guide? For players with fewer than 150 global points.

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is stuck in a local minimum, can you use the Foldit tools you just learned to improve the model and match the guide? For players with fewer than 15 global points.

This puzzle is designed for veteran Foldit players to help new players, and since it was up recently this version of the puzzle is only worth 10 global points.