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Puzzle
Expired: 09/22/17 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,687
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 10/26/17 23:00:00
Top Group: GENE 433
Top Player: Maerlyn138
Top Score: 14,430
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expired: 09/20/17 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,991
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. This protein contains four cysteine residues, but in this state only two of them are expected to oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/15/17 23:00:00
2 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,199
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 65 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/15/17 12:00:00
6 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 9,218
Categories: Experimental
This small protein is involved in signaling within the immune system. In this experimental puzzle you will have 250 moves at your disposal. Once you use them up, you can reset and try something else!
Puzzle
Expired: 09/12/17 12:00:00
9 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,226
Categories: Experimental
This small signaling protein is found in lymphoid tissue and participates in the immune response by attracting white blood cells.
Puzzle
Expired: 10/19/17 23:00:00
Top Group: xkcd
Top Player: Mohambone
Top Score: 9,248
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expired: 09/13/17 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,700
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. Ubiquitin is a well-known protein that helps to regulate the natural turnover of proteins in the cell, and this starting structure is a model of the protein produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/08/17 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: eromana
Top Score: 11,040
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 95-120 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/07/17 23:00:00
9 comments
Top Group: Gargleblasters
Top Player: eromana
Top Score: 10,410
Categories: Overall, Predicted Contacts, Prediction
This is a follow-up puzzle for Puzzle 1420, now with Predicted Contacts to help guide your folding! See the blog for information on using the contact map. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of green, with brighter green contacts indicating stronger predictions. Players will be able to load in manual saves from Puzzle 1420 and use them as a starting point here.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons