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Puzzle
Expired: 08/19/19 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,764
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (with no disulfide bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/14/19 23:00:00
1 comment
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 20,569
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. We've omitted the "Core Exists: Complex" objective to simplify the puzzle, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/11/19 23:00:00
1 comment
Top Group: Go Science
Top Player: NinjaGreg
Top Score: 10,863
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 08/12/19 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,200
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This spinach protein is critical for photosynthesis, and participates in the electron transfer chain within the chloroplast. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/07/19 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,095
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 08/07/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 22,236
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/03/19 23:00:00
1 comment
Top Group: Void Crushers
Top Player: Timo van der Laan
Top Score: 10,789
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 08/05/19 18:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 15,628
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is able to absorb light and use the energy to transfer chloride ions across the cell membrane. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 07/30/19 23:00:00
3 comments
Top Group: Contenders
Top Player: georg137
Top Score: 11,227
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 07/31/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 18,582
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons