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Puzzle
Expired: 12/11/17 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 11,118
Categories: Design, Overall
This puzzle challenges players to design a protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 12/10/17 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,179
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 01/11/18 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: histon
Top Score: 9,335
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expired: 12/13/17 23:00:00
5 comments
Top Group: Anthropic Dreams
Top Player: tokens
Top Score: 23,106
Categories: Design, Overall
This is the fourth puzzle of our Aflatoxin Challenge; now players may insert and delete residues in solutions from the previous Round 3 puzzle. Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. Players may add up to 20 additional residues within these loops, at a cost of 16 points per residue. Players may load in solutions from Puzzle 1450.
Puzzle
Expired: 12/04/17 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 10,497
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 75 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 12/05/18 16:00:00
The goal of this puzzle is to change the chemical structure of the ligand in the center of the protein to find better inhibitors of HIV protease. It's less about changing the protein to bind the ligand, and more about changing the ligand to fit the protein. Use the Ligand Design tool in the selection interface (or the "Ligand Design" mode in the original interface) to alter the chemical identity of the inhibitor.

Puzzle
Expired: 01/04/18 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: JSmith48
Top Score: 8,651
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expired: 11/25/17 03:00:00
Top Group: Go Science
Top Player: Hollinas
Top Score: 9,293
Categories: Experimental
This protein is involved in transcription regulation and gene expression. It is also associated with both colorectal and liver cancer. In this experimental puzzle you will have 250 moves at your disposal. Once you use them up, you can reset and try something else!
Puzzle
Expired: 11/27/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,979
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 11/21/17 03:00:00
1 comment
Top Group: Go Science
Top Player: Azukay
Top Score: 9,446
Categories: Experimental
This protein is involved in transcription regulation and gene expression. It is also associated with both colorectal and liver cancer.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons