Puzzles Feed

Closed

Puzzle
Expired: 11/16/17 23:00:00
Top Group: Russian team
Top Player: ralan-nsk
Top Score: 8,753
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expired: 10/10/17 23:00:00
2 comments
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 8,360
Categories: Design, Overall
This is a followup to Puzzle 1422. Redesign the loops of this protein to better bind the ligand! Nicotinamide mononucleotide (NMN) is a small-molecule that makes up part of the small-molecule nicotinamide adenine dinucleotide (NAD), which is sometimes regarded as 'the molecule of youth.' Scientists know that the amount of NAD in our cells declines as we age, and so designing a protein to bind to NMN is the first step towards achieving protein-based biosensors that can detect NMN levels in cells. Such biosensors would help scientists to understand the aging process and could potentially lead to a 'cure' for aging! In this puzzle, players have a little more freedom in redesigning the NMN binding pocket. Players may load in solutions from Puzzle 1422.
Puzzle
Expired: 10/06/17 23:00:00
2 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,064
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 11/09/17 23:00:00
Top Group:
Top Player: Anonymous
Top Score: 11,088
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 10/04/17 23:00:00
14 comments
Top Group: Go Science
Top Player: isaksson
Top Score: 8,358
Categories: Experimental
Note: Due to player feedback and an excessive number of bugs, this puzzle was closed early and is worth zero points.
Puzzle
Expired: 09/29/17 23:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: markm457
Top Score: 10,433
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 11/02/17 23:00:00
Top Group:
Top Player: Dutchpainter
Top Score: 8,943
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expired: 09/27/17 19:00:00
24 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 20,392
Categories: Experimental, Small Molecule Design
This is the first official small molecule design puzzle. The goal is to change the ligand in the center of the protein to find better inhibitors of HIV protease. Use the Ligand Design tool in the selection interface (or the "Ligand Design" mode in the original interface) to alter the chemical identity of the inhibitor. See the blog post for more information on the puzzle and small molecule design.
Puzzle
Expired: 10/30/17 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,930
Categories: Overall, Prediction
Chikungunya (CHIK-un-goon-ya) virus (also known as CHIKV) is a mosquito-transmitted alphavirus that has spread around the world and is currently infecting people in about 60 countries globally. CHIKV is rarely fatal, but causes severe joint pain for months to years that can debilitate affected patients for long periods of time. There are currently no known drugs to treat CHIKV infection, primarily due to a lack of understanding of the structure of CHIKV proteins involved in viral genome replication. The Geiss lab has worked on developing drug targeting the membrane bound CHIKV nsP1 protein, which is the anchor for the viral genome replication complex on cellular membranes and a multifunctional enzyme that forms a 5’ RNA cap structure on the end of the CHIKV RNA genome. Solving the structure of the CHIKV nsP1 protein would provide critical information for designing drugs that inhibit nsP1 function and abort viral genome replication.
Puzzle
Expired: 10/09/17 23:00:00
9 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,228
Categories: Overall, Prediction
Note: In response to some player feedback related to the excessive size of this protein, we're extending the puzzle deadline by two weeks! The puzzle will expire on October 9 at 23:00 UTC.
Get Started: Download
  Windows    OSX    Linux  
Windows
(Vista/7/8)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons