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Puzzle
Expired: 03/11/21 18:00:00
1 comment
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 10,100
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. These are the two chains of a bio-engineered variant of human insulin, which contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.
Puzzle
Expired: 03/12/21 23:00:00
6 comments
Top Group: Gargleblasters
Top Player: Skippysk8s
Top Score: 39,705
Categories: Design, Overall
This is the fifteenth puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! One of them is LCB3 which you have seen before, but the one without any adjoining spike is called AHB2, and is another de novo protein that is meant to mimic ACE2, which is the human protein that SARS-CoV-2 binds to when it infects your cells. The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned.
Puzzle
Expired: 03/31/21 23:00:00
Top Group: Gargleblasters
Top Player: OWM3
Top Score: 24,523
Categories:
This sandbox puzzle features a symmetric tetramer assembly, designed by Galaxie in Puzzle 1950. This design has excellent close packing of core residues! All of the hydrophobic residues at the interface should make for tight binding, but all of the exposed hydrophobics may cause trouble for proper folding. For more, check out Foldit Lab Report #18 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Puzzle
Expired: 03/05/21 23:00:00
1 comment
Top Group: Go Science
Top Player: ichwilldiesennamen
Top Score: 18,327
Categories: Design, Overall
Design a protein to bind to influenza virus! This puzzle is much like Puzzle 1956, but without the Move Limit. We've also doubled the bonus for DDG and Contact Surface Objectives, and increased the penalty for BUNS. We hope that players will be able to max out these Objectives!
Puzzle
Expired: 03/04/21 18:00:00
8 comments
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 10,623
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This scorpion toxin is similar to the one from Puzzle 55, and binds to voltage-gated ion channels of insects. The protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 03/03/21 23:00:00
1 comment
Top Group: Contenders
Top Player: georg137
Top Score: 22,275
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 02/26/21 23:00:00
5 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 24,588
Categories: Design, Overall
Design an interface between two protein chains! This puzzle is much like Puzzle 1950 but we've piled on some more Objectives to reward a H-bond Network at the interface, as well as a single disulfide bond at the interface. In this two-sided design puzzle, you can mutate the interface residues of both chains A and B, but you may only shape the backbone of chain A. The goal is to create a binding interface between the two protein chains so that they will stick together in solution. However, the starting position of the two chains is important, so the locked regions are held in place by strong constraints. The only way to make the two chains bind will be to fold up a brand new interface between them.
Puzzle
Expired: 02/25/21 18:00:00
8 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 17,468
Categories: Electron Density, Overall, Prediction
This is a followup to Puzzle 1952, now starting from the structure that was originally published. This protein is part of a large protein complex with multiple subunits, which was recently solved by cryo-electron microscopy (cryo-EM) at 4.2A resolution. Unfortunately, the solved structure could really use some work so we are hoping you can improve the structure. The starting structure also includes several locked protein fragments in the electron density cloud. These are additional proteins that are also present, and are expected to make interactions with the final folded structure. Good luck!
Puzzle
Expired: 02/24/21 23:00:00
1 comment
Top Group: Go Science
Top Player: Dhalion
Top Score: 40,179
Categories: Design, Overall
This is the fourteenth puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! One of them is LCB3 which you have seen before, but the one without any adjoining spike is called AHB2, and is another de novo protein that is meant to mimic ACE2, which is the human protein that SARS-CoV-2 binds to when it infects your cells. The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned.
Puzzle
Expired: 02/19/21 23:00:00
6 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 16,254
Categories: Design, Overall
Design a protein to bind to influenza virus! This puzzle has a Move Limit of 250 moves; after that, you will be unable to improve your solution, but you can restart the puzzle to reset your move count. The Move Limit is meant to encourage players to try multiple solutions to the puzzle, instead of spending a lot of time optimizing a single solution.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons