Puzzles Feed

Closed

Puzzle
Expired: 05/25/17 18:00:00
Top Group: Beta Folders
Top Player: smilingone
Top Score: 8,933
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is found in the nucleus of stem cells in mice, and is important for maintaining the pluripotency of the stem cell. The protein is modeled here as in a reduced environment, so no disulfide bonds are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/29/17 23:00:00
Top Group: GUGITBIOTECH
Top Player: spode
Top Score: 8,984
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expired: 05/22/17 23:00:00
13 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,112
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1378, which was incorrectly calibrated for scoring. Players may load in solutions from Puzzle 1378.
Puzzle
Expired: 05/22/17 23:00:00
13 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 0
Categories:
Note: This puzzle was closed early due to an error in the baseline score. The puzzle has been reposted as Puzzle 1378.
Puzzle
Expired: 05/19/17 23:00:00
3 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,238
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 05/18/17 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 9,317
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a portion of a troponin protein found in the skeletal muscle of turkeys. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/22/17 23:00:00
Top Group: Anthropic Dreams
Top Player: thewholeblahthing
Top Score: 14,789
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expired: 05/15/17 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,834
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 05/11/17 18:00:00
Top Group: Contenders
Top Player: gitwut
Top Score: 8,626
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a trypsin inhibitor in pumpkins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
Puzzle
Expired: 06/15/17 23:00:00
Top Group: Go Science
Top Player: Bobnine
Top Score: 8,857
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons