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Puzzle
Expired: 04/02/21 23:00:00
2 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 10,003
Categories: Design, Overall
Design a protein to bind to the Tie2 receptor! Tie2 is a human protein that helps to regulate the maintenance and growth of blood vessels throughout the body. Normally, the Tie2 receptor binds a growth factor called angiopoietin, a signaling molecule that triggers the growth of new blood vessels. However, Tie2 overactivity has been implicated in several types of cancer, since rapidly-growing tumors require lots of new blood vessels to provide nutrients. We want to design a protein that could bind to Tie2 and block angiopoietin. A successful binder might be useful as a drug to modulate Tie2 activity that is necessary for tumor growth.
Puzzle
Expired: 04/01/21 18:00:00
2 comments
Top Group: Go Science
Top Player: fiendish_ghoul
Top Score: 17,837
Categories: Electron Density, Overall, Prediction
Fold this CMG2 protein into the electron density map! This protein is a domain of the human capillary morphogenesis protein 2 (CMG2). The CMG2 protein normally associates with other proteins in connective tissue, and is thought to be important for the formation of new blood vessels. But CMG2 is also targeted by the anthrax toxin, and has been implicated in certain types of cancer. The protein in this puzzle is a variant of CMG2 that researchers are studying to better understand its structure and function. This electron density map comes from x-ray crystallography experiments, and outlines the shape of the folded protein. Help us determine the structure of this CMG2 variant by folding it in the electron density!
Puzzle
Expired: 03/31/21 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 24,012
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 03/25/21 18:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 10,135
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small, intracellular domain binds to the CD2 T cell receptor (TCR), and plays a critical role in T cell activation during the immune response. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 03/24/21 23:00:00
1 comment
Top Group: Marvin's bunch
Top Player: jausmh
Top Score: 20,948
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 03/26/21 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: Jpilkington
Top Score: 10,870
Categories: Design, Overall
This puzzle is part of a special binder design competition. We are challenging Foldit players to design as many proteins as possible in this special two week puzzle. When you reach 10,000 points, submit your solution for the competition using the Upload for Scientists button, and reset the puzzle to start another submission! This puzzle is much like Puzzle 1962, with a scoring offset (a score of 10,000 here is about equivalent to 17,500 in Puzzle 1962). See the blog for more details about the competition. For players that do not wish to participate in the competition, this puzzle will also function like a regular puzzle, and will award Foldit points as usual when the puzzle expires.
Puzzle
Expired: 03/17/21 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: Blipperman
Top Score: 19,163
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 03/18/21 18:00:00
40 comments
Top Group: Go Science
Top Player: mirp
Top Score: 18,724
Categories: Electron Density, Overall
We are very excited about this puzzle, because our collaborators who provided us with the 4 structures from Foldit's 2019 cryo-EM paper have been unable to solve this cryo-EM structure.
Puzzle
Expired: 03/10/21 23:00:00
1 comment
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 17,858
Categories: Design, Overall
Design an interface between two protein chains! This puzzle starts with a fully-folded interface, but you will need to refold it in order to get credit. The Exploration Objective checks how closely your solution matches the starting structure, and any solution with RMSD < 3.0 A will not receive credit! We're hoping that Foldit players can find high-scoring variations on this starting structure. See the blog for more details.
Puzzle
Expired: 03/11/21 18:00:00
1 comment
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 10,100
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. These are the two chains of a bio-engineered variant of human insulin, which contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons