Puzzles Feed

Closed

Puzzle
Expired: 11/19/20 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 20,445
Categories:
Note: This puzzle was closed early due to a bug in the Contact Surface metric, and is reposted as Puzzle 1916b. Players may load solutions from this puzzle into the reposted version.
Puzzle
Expired: 11/20/20 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,044
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein was evolved in vitro to bind testosterone; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.
Puzzle
Expired: 11/18/20 23:00:00
10 comments
Top Group: Go Science
Top Player: mirp
Top Score: 36,545
Categories: Design, Overall
This is the second puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned. We have also included the parts of the actual spike that are within 20 angstroms of the termini of the helices on the binders, so you know what regions your binder has to avoid to prevent clashing. The designable helices are a possible starting point for your linker designs.
Puzzle
Expired: 11/13/20 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,908
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 11/12/20 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: HuubR
Top Score: 15,529
Categories: Design, Overall
Design a binder for the viral spike of MERS-CoV! This puzzle is similar to Puzzle 1910, except that the Foldit Metrics will award increasing bonuses as you improve the DDG, SASA, and SC of your solution. The Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. See the blog for more info about Foldit Metrics.
Puzzle
Expired: 11/11/20 23:00:00
4 comments
Top Group: Gargleblasters
Top Player: HuubR
Top Score: 40,299
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1912 which was posted with an erroneous BUNS Objective. Players may not load solutions from the original Puzzle 1912.
Puzzle
Expired: 11/11/20 23:00:00
2 comments
Top Group: Go Science
Top Player: johnmitch
Top Score: 0
Categories:
Note: Due to an error with the BUNS Objective, this puzzle was closed early and reposted as Puzzle 1912b.
Puzzle
Expired: 11/30/20 23:00:00
Top Group: Italiani Al Lavoro
Top Player: g_b
Top Score: 20,460
Categories:
This sandbox puzzle features a symmetric trimer design by CharlieFortsConscience, from Puzzle 1900. It is difficult to form a well-shaped trimer interface with sheets, but this design has very few voids at the interface!. For more, check out Foldit Lab Report #14 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Puzzle
Expired: 11/06/20 18:00:00
6 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,581
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. This protein contains four cysteine residues, but in this state only two of them are expected to oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 11/05/20 23:00:00
5 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 17,539
Categories: Design, Overall
Design a binder for the viral spike of MERS-CoV! This puzzle is similar to Puzzle 1907, but now includes special Foldit Metrics for the DDG, SASA, and SC of your solution. These Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. Each Metric has a target, players will receive a 1000 pt bonus for meeting each target. See the blog for more info about Foldit Metrics.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons