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The starting structure should probably pass this 40% Core Exists filter. It looks like the filter is not behaving the same across all symmetric chains.

Here is another puzzle from the early days of Foldit. This is a protein that binds to the cytoplasmic domain of the T-cell Receptor. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

This is Round 2 for Puzzle 721. You will be able to load in your manual saves from 721 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch!

This is a throwback puzzle to the early days of Foldit. This protein is championed as the holy grail of neuroengineering. It functions to absorb light of a certain wavelength, and in response, it opens up a chloride channel. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. For players with fewer than 150 global points.

This is a throwback puzzle to the early days of Foldit. This protein is championed as the holy grail of neuroengineering. It functions to absorb light of a certain wavelength, and in response, it opens up a chloride channel. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. For players with fewer than 15 global points.

This is a throwback puzzle to the early days of Foldit. This protein is championed as the holy grail of neuroengineering. It functions to absorb light of a certain wavelength, and in response, it opens up a chloride channel. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

This is a 60 residue symmetric tetramer design puzzle. The starting structure is a solution to Puzzle 691 that was shared with us by MurloW. The scientists at the Baker Lab like the topology of this solution, but simulations predict that this amino acid sequence will not fold up properly from an extended chain. Help us redesign this solution into a folding protein! The ResidueIE and "Core Exists" filters will make sure PHY, TYR, and TRP residues are scoring well, and that the protein core includes at least 35% of the residues. We look forward to seeing your mutations to this fold, although you are free to redesign the entire protein in this puzzle.

This Electron Density puzzle is going to be as difficult as they get! Why? Because the automated methods for fitting electron density were unable to solve this structure using this density. But where computers fail, Foldit players triumph! Use all your Electron Density folding skills to fit the density as well as you can. As requested in the last Scientist Chat, we have added secondary structure predictions onto the starting model, with more details posted in the puzzle comments.

We are giving you non-Rosetta server predictions for this CASP ROLL target. Resetting the puzzle will cycle through 5 different Zhang Server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else. The secondary structure predictions are provided on the extended chain in the Alignment Tool... for real, this time!