Puzzles Feed

Closed

Puzzle
Expired: 09/01/19 23:00:00
11 comments
Top Group: Go Science
Top Player: fiendish_ghoul
Top Score: 11,725
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/02/19 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,490
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This DNA-binding domain is part of a bacterial integrase protein, which facilitates the insertion of new DNA into the bacterial chromosome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/28/19 23:00:00
3 comments
Top Group: Go Science
Top Player: NinjaGreg
Top Score: 11,669
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 08/28/19 23:00:00
2 comments
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 19,177
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. We've omitted the "Core Exists: Complex" objective to simplify the puzzle, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/24/19 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,806
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 08/26/19 18:00:00
1 comment
Top Group: Go Science
Top Player: RockOn
Top Score: 10,361
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to transfer electrons between substrates in bacteria. The protein is modeled here in reducing conditions, and no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/20/19 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,684
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 08/21/19 23:00:00
6 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 23,624
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/17/19 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: Waya
Top Score: 11,597
Categories: Design, Overall
Note: This puzzle was mistakenly set to close on August 19. The puzzle close date has been reset to August 17, at 23:00, to keep the number of open puzzles at a reasonable level.
Puzzle
Expired: 08/19/19 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,764
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (with no disulfide bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons