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Puzzle
Expired: 03/19/20 23:00:00
17 comments
Top Group: Go Science
Top Player: Dj-P
Top Score: 15,450
Categories: Design, Overall
Design a binder against coronavirus! This is Foldit's third coronavirus puzzle, which challenges players to design an antiviral protein that could bind to the 2019 virus and disrupt viral infection. This puzzle provides a helix fragment that is already known to bind to the coronavirus, and Foldit players can design a new protein that includes this fragment. Players should focus on building up a protein with a large core of orange hydrophobics, and the best designs will also make additional contacts with the target. See our latest video update or the Foldit blog for tips about designing a successful binder! Solutions from previous puzzles are incompatible with this puzzle, so players may NOT load in previous work.
Puzzle
Expired: 03/18/20 18:00:00
3 comments
Top Group: Go Science
Top Player: Serca
Top Score: 10,222
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small domain is a component of the collagen that forms the connective tissue beneath your skin! This protein contains six cysteines that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 03/13/20 23:00:00
1 comment
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 21,678
Categories: Design, Overall, Symmetry
Design a symmetric trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective so that no more than 50% of residues may form helices. The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 03/12/20 23:00:00
8 comments
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 16,004
Categories: Design, Overall
Design a binder against coronavirus! This is a followup to Puzzle 1805b, which challenged players to design an antiviral protein that could bind to the 2019 coronavirus and disrupt viral infection. This puzzle has some small improvements, and allows players to continue working on antiviral designs. See the Foldit blog for a quick look results from Puzzle 1805b, with some tips for making a successful protein binder! Players may load in solutions that were saved in the previous puzzle.
Puzzle
Expired: 03/11/20 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,830
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. Signals from the nervous system induce Ca2+ release within muscle cells. This muscle protein, which normally inhibits muscle contraction, changes shape in the presence of Ca2+ to allow muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 03/06/20 23:00:00
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 10,126
Categories: Design, Overall
Refold the loops in this Aflatoxin Challenge design! This puzzle is similar to Puzzle 1803, but the starting structure comes from a different Foldit player design. After Round 13 of the Aflatoxin Challenge, where Foldit players redesigned the binding loops of an oxidation enzyme, the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design! If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!
Puzzle
Expired: 03/05/20 23:00:00
9 comments
Top Group: Go Science
Top Player: RockOn
Top Score: 16,812
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1805, in which some tools were unintentionally disabled. Players may load in solutions from Puzzle 1805.
Puzzle
Expired: 03/05/20 23:00:00
4 comments
Top Group: Beta Folders
Top Player: pvc78
Top Score: 15,704
Categories:
Note: This puzzle was closed early because some tools were unintentioally disabled; the puzzle has been reposted as Puzzle 1805b. Players may load solutions into the reposted Puzzle 1805b.
Puzzle
Expired: 03/04/20 18:00:00
4 comments
Top Group: Go Science
Top Player: mirp
Top Score: 10,484
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein recruits components of the immune system, and normally keeps white blood cells concentrated in the lymph nodes. However, it also plays a part in the inflammatory response, when immune cells are required to fight an infection. This protein contains four cysteines that oxidize to form two disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with easier puzzles that are still scientifically relevant.
Puzzle
Expired: 02/28/20 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,160
Categories: Overall, Prediction
Refold the loops in this Aflatoxin Challenge design! After Round 13, where Foldit players redesigned the binding loops of an oxidation enzyme, the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design! If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons