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Puzzle
Expired: 10/31/21 23:00:00
Top Group: Go Science
Top Player: toshiue
Top Score: 13,416
Categories:
This sandbox puzzle features a binder design by nspc in Puzzle 2043: CD47 Binder Design. This design makes excellent hydrophobic contacts with the CD47 target and does a good job of satisfying buried polar atoms with H-bonds. For more, check out Foldit Lab Report #25 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Puzzle
Expired: 10/07/21 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,891
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, which is released by the sea anemone A. xanthogrammica, disrupts normal contraction of cardiac muscle in potential predators, and furthermore serves as a pheromone to signal danger to nearby anemones. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 10/06/21 23:00:00
5 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 25,260
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 60 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 10/01/21 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: HuubR
Top Score: 13,605
Categories: Design, Overall
Design a protein that can bind to CD47! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expired: 09/30/21 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,428
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Chinese cobra N. atra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/29/21 23:00:00
1 comment
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 24,867
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 90 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 09/24/21 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Beany
Top Score: 10,946
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expired: 09/23/21 18:00:00
1 comment
Top Group: Gargleblasters
Top Player: Skippysk8s
Top Score: 10,443
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Mozambique spitting cobra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues, which oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/22/21 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 21,368
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 70 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 09/17/21 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 13,531
Categories: Design, Overall
Design a protein that can bind to CD47! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons