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Puzzle
Expired: 11/25/21 18:00:00
1 comment
Top Group: Contenders
Top Player: guineapig
Top Score: 9,804
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small disulfide-rich protein is produced by the moth H. virescens as a defense against certain bacterial and fungal infections. This protein contains six cysteines that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/24/21 23:00:00
1 comment
Top Group: Go Science
Top Player: Aubade01
Top Score: 22,291
Categories: Overall, Small Molecule Design
Design a small molecule which can bind VHL! This is the third in a series of puzzles using the small molecule design tools to design small molecule binders to the von Hippel-Lindau E3 ubiquitin ligase. We don't want you to modify the protein, but instead we'd like you to build new small molecules which fit into the VHL pocket. See the new "Inside the Pocket" and "Fun with Fragments!" tutorials to learn how to use the small molecule design tools.
Puzzle
Expired: 11/19/21 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 20,039
Categories: Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 60 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 11/18/21 18:00:00
1 comment
Top Group: Go Science
Top Player: silent gene
Top Score: 11,357
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small domain is part of a larger protein found at high concentrations of the lens of the eye; historically, this protein was purified from the eyes of B. taurus for research. The protein is modeled here in reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/17/21 23:00:00
9 comments
Top Group: Go Science
Top Player: Aubade01
Top Score: 22,212
Categories: Overall, Small Molecule Design
Design a small molecule which can bind VHL! This is the third in a series of puzzles using the small molecule design tools to design small molecule binders to the von Hippel-Lindau E3 ubiquitin ligase. We don't want you to modify the protein, but instead we'd like you to build new small molecules which fit into the VHL pocket. See the new "Inside the Pocket" and "Fun with Fragments!" tutorials to learn how to use the small molecule design tools.
Puzzle
Expired: 11/12/21 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,907
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expired: 11/11/21 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,665
Categories: Overall, Prediction
We previously gave you 5 server predictions to solve the structure of the human astrovirus (HAstV) capsid protein. This time we are providing you with 1 prediction from the HHpred server to work with. Good luck!
Puzzle
Expired: 11/10/21 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 24,121
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains of 90 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 11/30/21 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 25,845
Categories:
This sandbox puzzle features a symmetric design by Skippysk8s, Enzyme, and an anonymous teammate in Puzzle 2050: Symmetric D2 Tetramer Design. This design has several polar residues that form a fully satisfied H-bond network buried at the interface between subunits. The polar atoms in this H-bond network will help ensure correct assembly, since these polar atoms are likely to create unstable BUNS in off-target assemblies. For more, check out Foldit Lab Report #26 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Puzzle
Expired: 11/05/21 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 13,337
Categories: Design, Overall
Design a protein that can bind to CD47! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons