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Puzzle
Expires: 07/10/15 23:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: phi16
Top Score: 13,509
Categories: Design, Overall, Symmetry
This puzzle combines the new HBNet filter with full-blown symmetric design. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 08/13/15 23:00:00
Top Group: Gargleblasters
Top Player: Hands99
Top Score: 9,091
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 07/08/15 23:00:00
2 comments
Top Group: Gargleblasters
Top Player: gurra66
Top Score: 10,531
Categories: Design, Overall
Based on the results from Puzzle 1073: Marburg Binder Design with Disulfides (see the feedback on the Foldit blog for an idea of what we're looking for), we'd like to revisit this design target. The Marburg virus is a cousin of the Ebola virus, and causes a similarly deadly hemorrhagic fever. The largest outbreak, in 2004, had a 90% mortality rate. Understandably, we'd like an anti-viral agent to treat this disease.
Puzzle
Expires: 07/07/15 11:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,471
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 08/06/15 23:00:00
Top Group: xkcd
Top Player: napen123
Top Score: 8,627
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 07/30/15 23:00:00
Top Group: Dnice.dk
Top Player: pumtex
Top Score: 8,728
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 07/23/15 23:00:00
Top Group: Team Schleswig-Holstein
Top Player: SpikRMX
Top Score: 11,168
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 07/16/15 23:00:00
Top Group: PunBioSummer
Top Player: Verne
Top Score: 9,127
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 07/09/15 23:00:00
Top Group: Anthropic Dreams
Top Player: TJOK fan
Top Score: 14,718
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 07/02/15 23:00:00
1 comment
Top Group: Beta Folders
Top Player: Angus
Top Score: 10,597
Categories: Design, Overall
This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe