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Puzzle
Expires: 12/02/14 19:00:00
13 comments
Top Group: Anthropic Dreams
Top Player: johnmitch
Top Score: 12,753
Categories: Design, Overall, Symmetry
It's been a long time since our last Symmetric Design puzzle, and Foldit has seen a lot of improvements in the mean time! This puzzle uses two "Core Existence" filters. One checks that the monomer unit of your design contains a well-packed core, and another ensures that the entire symmetric complex has a buried core. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 11/28/14 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: MurloW
Top Score: 10,515
Categories: Design, Overall
This puzzle uses the updated Core Existence filter, and has a slightly lower threshold for identifying "core" residues. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 01/01/15 23:00:00
Top Group: CHEM237F2014
Top Player: Mouq
Top Score: 8,418
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 11/26/14 11:00:00
1 comment
Top Group: Beta Folders
Top Player: reefyrob
Top Score: 9,566
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is a phosphatase that participates in several metabolic pathways. The starting structure is a Rosetta model. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 12/01/14 14:00:00
3 comments
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 9,103
Categories: Overall, Prediction
We are again giving you this unsolved vascular endothelial growth factor protein, but this time with 5 Zhang Server predictions as starting points. Resetting the puzzle will cycle through each model. We are giving you 2 weeks to work on this puzzle, so please try out each server start. Although one server model scores better than the rest initially, it might be the furthest from the native and might not get you the most points in the end! SAM secondary structure predictions are in the puzzle comments.
Puzzle
Expires: 12/25/14 23:00:00
Top Group: USD_IMB_2014
Top Player: delawarekid
Top Score: 11,212
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 12/18/14 23:00:00
2 comments
Top Group: Oma Gawd
Top Player: UCDSciEnqK
Top Score: 9,134
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 12/11/14 23:00:00
Top Group: DCC Folders
Top Player: jstoddard
Top Score: 14,448
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 12/04/14 23:00:00
Top Group: DCC Folders
Top Player: Fixxitguy
Top Score: 9,445
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 11/27/14 23:00:00
Top Group: DCC Folders
Top Player: jstoddard
Top Score: 8,660
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe