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Puzzle
Expires: 04/04/15 11:00:00
Top Group: Go Science
Top Player: mirp
Top Score: 8,677
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to transfer electrons between substrates in bacteria. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 04/02/15 07:00:00
6 comments
Top Group: Beta Folders
Top Player: Goochie
Top Score: 12,691
Categories: Design, Overall, Symmetry
This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 05/07/15 23:00:00
Top Player: ivalnic5
Top Score: 8,356
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 04/03/15 09:00:00
1 comment
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 9,116
Categories: Overall, Prediction
The first two puzzles for this protein were able to significantly improve the structure of domain 6 of this protein, so we are giving you a different domain this time, with 5 Zhang Server predictions as starting points. Resetting the puzzle will cycle through each model. We are giving you 2 weeks to work on this puzzle, so please try out each server start. Although one server model scores better than the rest initially, it might be the furthest from the native and might not get you the most points in the end! More info in the puzzle comments.
Puzzle
Expires: 04/30/15 23:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 11,087
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 04/23/15 23:00:00
Top Group: Go Science
Top Player: auronvolgar
Top Score: 9,077
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 04/16/15 23:00:00
2 comments
Top Group: Russian team
Top Player: SIW
Top Score: 14,897
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 04/02/15 23:00:00
Top Group: Gargleblasters
Top Player: zeroblue
Top Score: 8,644
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 04/09/15 23:00:00
Top Group: Russian team
Top Player: donneaux
Top Score: 9,219
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 03/27/15 11:00:00
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 9,643
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (without disulfides bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe