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Puzzle
Expires: 12/04/14 23:00:00
Top Group: Rice Biochemistry
Top Player: pizpot
Top Score: 8,444
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 10/30/14 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,866
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 10/28/14 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,102
Categories: Overall, Prediction
In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. Secondary structure predictions from the SAM server are currently unavailable, but the starting model includes secondary structure as predicted by PSIPRED.
Puzzle
Expires: 10/29/14 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Blipperman
Top Score: 9,501
Categories: Design, Overall
This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 10/27/14 23:00:00
26 comments
Top Group: Go Science
Top Player: gloverd
Top Score: 11,193
Categories: Design, Overall
For our one thousandth puzzle, we've got a particularly challenging task for you. We have posted a few past puzzles in which we have asked players to design peptides and small proteins that are able to bind to a binding site on the Ebola binding protein. The glycoprotein uses this site to latch onto a human cell membrane protein as a first step in invading host cells, which means that something binding at this site should hinder viral entry into cells.

Puzzle
Expires: 11/20/14 23:00:00
Top Group: Structuralists
Top Player: Maru67
Top Score: 8,693
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 11/13/14 23:00:00
Top Group: Protein Pirates
Top Player: BlackyAlex
Top Score: 10,801
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 11/06/14 23:00:00
Top Group: Penn State Biomolecular Engineers
Top Player: qwertyui
Top Score: 9,286
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 11/27/14 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: pogiaron
Top Score: 8,634
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 10/30/14 23:00:00
Top Group: Go Science
Top Player: ChrissyH
Top Score: 15,777
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe