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Puzzle
Expires: 05/04/15 23:00:00
Top Group: Beta Folders
Top Player: Goochie
Top Score: 8,080
Categories: Hand-Folding, Overall, Prediction
In this de-novo freestyle puzzle, only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be reposted with LUA scripts and sharing enabled. The PSIPRED secondary structure predictions are provided on the starting model.
Puzzle
Expires: 05/02/15 11:00:00
Top Group: Gargleblasters
Top Player: Blipperman
Top Score: 8,986
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein domain is a component of the histone protein complex, which packages DNA into compact units called nucleosomes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 04/30/15 23:00:00
1 comment
Top Group: Contenders
Top Player: gitwut
Top Score: 13,862
Categories: Electron Density, Overall, Prediction
This protein was designed in the Baker Lab, but we've had a lot of difficulty solving its crystal structure! Use all your Electron Density folding skills to fit the density as well as you can.
Puzzle
Expires: 06/04/15 23:00:00
Top Group: 3FM2bioquimica
Top Player: icrf
Top Score: 8,924
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 05/28/15 23:00:00
Top Group: Go Science
Top Player: Restriction End...
Top Score: 14,918
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 05/21/15 23:00:00
Top Group: Anthropic Dreams
Top Player: jfryk
Top Score: 9,309
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 05/14/15 23:00:00
Top Group: BOINC@Poland
Top Player: kitek314_pl
Top Score: 8,651
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 05/07/15 23:00:00
Top Group: Gargleblasters
Top Player: p01arst0rm
Top Score: 8,684
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 04/30/15 23:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 11,437
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 04/27/15 23:00:00
1 comment
Top Group: Go Science
Top Player: gloverd
Top Score: 10,731
Categories: Design, Overall
In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe