As mentioned in Puzzle 558, we are giving you some server predictions for this CASP10 target. Resetting the puzzle will cycle through 6 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try to work on each of the 6 server models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!

This target is so tough, we aren't even sure of its topology! What we do believe is that one possible topology is a coiled coil (please look at the screenshot of a template in the puzzle comments) so we are giving you this model to fold using symmetry. We will post the other non-symmetric topologies as regular puzzles.

Yet another tough one! None of the alignment programs were able to find good templates for this target, and it might be the case that this protein has no homologs. We are giving you 7 templates (in hope that one of them is correct) for now, and will provide you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.

This is another tough one! None of the alignment programs were able to find good templates for this target, and it might be the case that this protein has no homologs. Again we are giving you 6 templates (in hope that one of them is correct) for now, and will provide you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide? For help with Intro Puzzles, visit http://tinyurl.com/foldit-help . Make sure you have completed the Intro Puzzles (at least up to Level 4-5) before attempting these more difficult Science Puzzles. For players with fewer than 150 global points.

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide? For help with Intro Puzzles, visit http://tinyurl.com/foldit-help . Make sure you have completed the Intro Puzzles (at least up to Level 4-5) before attempting these more difficult Science Puzzles. For players with fewer than 15 global points.

This puzzle is designed for veteran Foldit players to help new players, and since it was up recently this version of the puzzle is only worth 10 global points.

This puzzle is very similar to puzzle 557. Again, most of the server predictions for T0660 were very similar except for the last 50 residues. Getting this C-terminal region right will separate the best predictions from the worst ones for this CASP10 target. Focus on folding the last 50 residues with the rest of the protein. You can use the Alignment Tool to insert a cutpoint between these regions. More info in the puzzle comments.

Just to warn you: this one is going to be tough! None of the alignment programs were able to find good templates for this target, and it might be the case that this protein has no homologs. Therefore we are giving you 6 templates (in hope that one of them is correct) for now, and will provide you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.

Most of the server predictions for T0644 were very similar except for the first 32 residues (the region that was unaligned to the starting template). Getting this N-terminal region right (which is strongly predicted to be helical) will separate the best predictions from the worst ones for this CASP10 target. For this quick puzzle: focus on folding the first 32 residues with the rest of the protein. Please read the puzzle comments about fixing an error in the starting model!