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Puzzle
Expires: 04/25/14 23:00:00
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 10,513
Categories: Design, Overall
This is a single-chain design puzzle with 95 residues. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The High Wiggle Power option has been disabled, and the Fragment Filter has been omitted, although these tools may return in a followup refinement round. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 05/29/14 23:00:00
Top Group: Go Science
Top Player: egran48
Top Score: 10,555
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 04/23/14 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 8,819
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a small protein participates in electron transfer reactions in the cell. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
Puzzle
Expires: 04/21/14 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: karstenw
Top Score: 9,064
Categories: Overall, Prediction
In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Puzzle
Expires: 05/22/14 23:00:00
Top Group: Italiani Al Lavoro
Top Player: alfioalfio
Top Score: 9,189
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 05/15/14 23:00:00
Top Group: Italiani Al Lavoro
Top Player: Idiotboy
Top Score: 15,869
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 05/08/14 23:00:00
Top Group: FoldIt@Netherlands
Top Player: criziscience
Top Score: 9,020
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 05/01/14 23:00:00
Top Group: Go Science
Top Player: SuperEnzyme
Top Score: 8,763
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 04/24/14 23:00:00
Top Group: CHNO Junkies
Top Player: pmlkjn
Top Score: 8,781
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 04/18/14 23:00:00
2 comments
Top Group: Void Crushers
Top Player: Timo van der Laan
Top Score: 9,149
Categories: Overall, Prediction
NOTE: Due to a hiccup earlier today, two duplicate 875 puzzles were previously posted. Both of those puzzles have now been closed, but you may load in solutions from either of those puzzles.

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