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Puzzle
Expires: 04/30/14 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Incongruous
Top Score: 9,013
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This domain is a component of many proteins involved in cell signaling. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
Puzzle
Expires: 04/29/14 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: karstenw
Top Score: 9,073
Categories: Overall, Prediction
In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Puzzle
Expires: 04/29/14 23:00:00
Top Group: Anthropic Dreams
Top Player: karstenw
Top Score: 9,212
Categories: Overall, Prediction
This is a repost of Puzzle 876, now with the High Wiggle Power option enabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. Note that players will NOT be able to load in previous solutions from Puzzle 876.
Puzzle
Expires: 04/30/14 23:00:00
2 comments
Top Group: Anthropic Dreams
Top Player: Susume
Top Score: 3,818
Categories: Design, Overall
This is a design puzzle with 37 residues, near the interface of a target glycoprotein from the Ebola virus. At the binding site of the Ebola protein, there is already a helix designed by scientists in the Baker Lab, but the helix will not fold up by itself! Build a scaffold around the starting design that will fold up properly and stabilize the binding helix! There are strong constraints to keep the binding helix in place, and you may not mutate residues at the interface. You may not add additional residues to the design, but you may delete residues from one end of the design and reinsert them at the other end. You will receive an (extremely) large bonus for making up to 2 disulfide bonds. Remember to share your favorite designs using the Share with Scientist tool, even if those are not your best-scoring solutions!
Puzzle
Expires: 04/25/14 23:00:00
Top Group: Anthropic Dreams
Top Player: gmn
Top Score: 10,562
Categories: Design, Overall
This is a single-chain design puzzle with 95 residues. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The High Wiggle Power option has been disabled, and the Fragment Filter has been omitted, although these tools may return in a followup refinement round. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 05/29/14 23:00:00
Top Group: Go Science
Top Player: egran48
Top Score: 10,755
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 05/22/14 23:00:00
Top Group: Italiani Al Lavoro
Top Player: pmthomson90
Top Score: 9,205
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 05/15/14 23:00:00
Top Group: Italiani Al Lavoro
Top Player: Idiotboy
Top Score: 15,873
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 05/08/14 23:00:00
Top Group: Italiani Al Lavoro
Top Player: MuckeMcFly
Top Score: 9,023
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 05/01/14 23:00:00
Top Group: Go Science
Top Player: SuperEnzyme
Top Score: 8,763
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe