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Puzzle
Expires: 09/30/16 23:00:00
Top Group: Anthropic Dreams
Top Player: tokens
Top Score: 9,354
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expires: 11/03/16 23:00:00
Top Group: Rice Biochemistry
Top Player: godzig
Top Score: 8,479
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 09/28/16 18:00:00
3 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,774
Categories: Electron Density, Overall, Prediction
This is a repost of Puzzle 1284, now with an electron density map! This protein is found in high concentrations in the lens of the eye. Among its other functions, it is responsible for the high refractive index (and resulting optical properties) of the lens. The protein is modeled here in reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players may load in solutions from Puzzle 1284.
Puzzle
Expires: 10/27/16 23:00:00
Top Group: Void Crushers
Top Player: Mydogisa Toelicker
Top Score: 11,170
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 10/20/16 23:00:00
Top Group: Natural Abilities
Top Player: Mr_Jolty
Top Score: 9,109
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 10/13/16 23:00:00
Top Group: Minions of TWIS
Top Player: wolfy959
Top Score: 13,991
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 10/06/16 23:00:00
Top Group: Natural Abilities
Top Player: Ichigo
Top Score: 9,237
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 09/29/16 23:00:00
Top Group: Natural Abilities
Top Player: Mr_Jolty
Top Score: 8,706
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 09/23/16 23:00:00
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 9,657
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 09/22/16 23:00:00
9 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 10,429
Categories: Design, Overall
This puzzle is similar to recent design puzzles, but we'd like players to avoid using the Rebuild tool. We suspect that the Rebuild tool has been introducing some problematic backbones into Foldit player designs, so the Rebuild tool has been deactivated in this puzzle. In most cases, the Remix tool can be used as an alternative to Rebuild. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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