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Puzzle
Expires: 05/12/16 23:00:00
1 comment
Top Group: Go Science
Top Player: mirp
Top Score: 9,942
Categories: Design, Overall
This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 65 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 06/16/16 23:00:00
Top Group: BIL255UofM
Top Player: lobexevropa
Top Score: 8,889
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 05/12/16 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,058
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This pilin protein allows the P. aeruginosa bacterium to adhere to human cells, sometimes resulting in infection. The starting structure is a Rosetta model. This protein contains two cysteine residues which oxidize to form one disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 05/09/16 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,207
Categories: Overall, Predicted Contacts, Prediction
This is a follow-up puzzle for Puzzle 1224, now with Predicted Contacts to help guide your folding! See the blog for information on using the contact map. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of green, with brighter green contacts indicating stronger predictions. Players will be able to load in manual saves from Puzzle 1224 and use them as a starting point here.
Puzzle
Expires: 06/09/16 23:00:00
Top Group: Minions of TWIS
Top Player: johngran
Top Score: 14,079
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 06/02/16 23:00:00
Top Group: PSU Berks BMB465 Spring 2016
Top Player: chris1895
Top Score: 8,555
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 05/26/16 23:00:00
Top Group: D001x Med Chem MOOC
Top Player: heather-1
Top Score: 8,670
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 05/19/16 23:00:00
Top Group: Go Science
Top Player: Komeiji_Koishi
Top Score: 8,696
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 05/12/16 23:00:00
Top Group: Go Science
Top Player: Nachtara
Top Score: 11,044
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 05/05/16 23:00:00
1 comment
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 10,688
Categories: Design, Overall
This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 85 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe