Puzzles Feed

Current

Puzzle
Expires: 01/29/15 11:00:00
1 comment
Top Group: Beta Folders
Top Player: smilingone
Top Score: 9,717
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This scorpion toxin binds to voltage-gated ion channels in insects, resulting in full-body paralysis. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 01/28/15 20:00:00
1 comment
Top Group: Beta Folders
Top Player: Goochie
Top Score: 10,120
Categories: Design, Overall
In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 01/26/15 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: viosca
Top Score: 9,540
Categories: Hand-Folding, Overall, Prediction
In this de-novo freestyle puzzle, only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be reposted with LUA scripts and sharing enabled. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Puzzle
Expires: 02/05/15 23:00:00
Top Group: Void Crushers
Top Player: gurch
Top Score: 11,388
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 01/29/15 23:00:00
Top Group: Herobrine's Army
Top Player: wolvenmoonstone
Top Score: 9,214
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 01/22/15 11:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 8,892
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This kinase protein is part of a human signaling pathway that controls cell growth. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 01/21/15 18:00:00
6 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,524
Categories: Design, Overall
This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 01/19/15 23:00:00
Top Group: Void Crushers
Top Player: spmm
Top Score: 9,893
Categories: Overall, Prediction
This is Round 2 for Puzzle 1032. You will be able to load in your manual saves from 1032 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 1032, you can go back to 1032, manually save it, and the solution should appear in your manual saves for this puzzle.
Puzzle
Expired: 01/22/15 12:00:00
18 comments
Top Group: Gargleblasters
Top Player: gurra66
Top Score: 25,273
Categories: Design, Electron Density, Overall
This puzzle is unlike anything we have ever posted before! We have given you extremely accurate electron density, but no sequence information. This protein has 95-residues, but your starting model only has 5 Alanines that are floating in the density. You'll need to insert residues and mutate them as you make your way through the density. We know this won't be easy, some might even suggest that this task is impossible... but we know that if anyone can do it: you can!
Puzzle
Expired: 01/15/15 11:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,258
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is part of a metabolic pathway used by bacteria to harvest energy from sugars. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Get Started: Download
  Windows    OSX    Linux  
Windows
(XP/Vista/7/8)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe