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Puzzle
Expires: 11/06/14 23:00:00
Top Group: Anthropic Dreams
Top Player: johnmitch
Top Score: 9,398
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein was evolved in vitro to bind testosterone; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 12/11/14 23:00:00
Top Group: DCC Folders
Top Player: jstoddard
Top Score: 14,089
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 11/04/14 23:00:00
Top Group: Beta Folders
Top Player: smilingone
Top Score: 9,663
Categories: Overall, Prediction
In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. Secondary structure predictions from the SAM server are currently unavailable, but the starting model includes secondary structure as predicted by PSIPRED.
Puzzle
Expires: 11/03/14 23:00:00
Top Group: Anthropic Dreams
Top Player: jamiexq
Top Score: 9,731
Categories: Design, Overall
In this puzzle we'd like you to refine a Foldit player-designed protein. The starting structure is an alternate conformation predicted for a design by stomjoh from Puzzle 995. We think this design shows promise, but it needs some tweaking. This puzzle includes an Exploration filter to keep players from straying too far from the starting structure. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 12/04/14 23:00:00
Top Group: Go Science
Top Player: heterological name
Top Score: 9,242
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 11/20/14 23:00:00
Top Group: Structuralists
Top Player: Maru67
Top Score: 8,693
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 11/13/14 23:00:00
Top Group: FoldIt@Netherlands
Top Player: hiker2180
Top Score: 11,101
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 11/06/14 23:00:00
2 comments
Top Group: Penn State Biomolecular Engineers
Top Player: qwertyui
Top Score: 9,286
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 11/27/14 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: pogiaron
Top Score: 8,634
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 10/30/14 23:00:00
3 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,904
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe