Puzzles Feed


Expires: 08/27/14 14:00:00
Top Group: Gargleblasters
Top Player: GaryForbis
Top Score: 9,885
Categories: Overall, Predicted Contacts, Prediction
All CASP11 submission deadlines have passed, but our analysis of the results has just begun! This contact map puzzle is based on the same target as Puzzle 966, and we want to see if you can improve a model from one of the competing servers. Instead of starting this puzzle with an extended chain, we've provided a model that satisfies a large number of contacts. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 2775 possible points from the filter. Players will NOT be able to load solutions from Puzzle 966.
Expires: 08/28/14 23:00:00
Top Group: SETI.Germany
Top Player: Batz
Top Score: 9,869
Categories: Design, Overall
In this design puzzle, we're encouraging players to incorporate PRO residues in the loops of their designs, so PRO residues will score more favorably than normal. Players will receive a 500 point bonus from the Secondary Structure filter if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. The Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Expires: 10/02/14 23:00:00
Top Player: FHRITP
Top Score: 11,150
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Expires: 08/27/14 14:00:00
Top Group: Go Science
Top Player: sheerbliss
Top Score: 13,144
Categories: Design, Overall
We would like you to design a small (25-residue) peptide that can bind to and block the Ebola glycoprotein. The glycoprotein is a viral surface protein that allows the Ebola virus to enter human cells. A small peptide inhibitor of this protein would therefore represent a candidate therapeutic for treating this deadly disease. We are starting you with a hotspot "stub" that was the top-scoring result from the earlier stub-finding puzzle, number 846. (Congratulations to AnthropicDreams!) We have extended this stub with twenty-two additional residues that you can design. A small peptide in this size range probably won't fold the way a protein would. Some considerations -- good hydrophobic packing, lack of holes in the core, good hydrogen bonding, presence of secondary structure, etc. -- will be the same, but in addition, heavy disulfide cross-linking is often necessary for stability in this size range. You will get a considerable bonus for forming up to three disulfide bonds (for a total of five, counting the two disulfide bonds already present in the Ebola target protein). Many natural plant and animal toxins are small peptides, and it is common to see three disulfide bonds in a "leapfrog" pattern (i.e. cys1-cys4, cys2-cys5, cys3-cys6) for maximal stability. The starting point for this puzzle has three disulfides in this "leapfrog" pattern, but this might not be the optimal disulfide placement or backbone topology. Feel free to change the secondary structure, move the disulfides around, or otherwise improve on this!
Expires: 08/24/14 23:00:00
Top Group: Go Science
Top Player: gloverd
Top Score: 8,790
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is found in cold water fishes; it binds and prevents the growth of ice crystals. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
Expires: 09/25/14 23:00:00
Top Group: Anthropic Dreams
Top Player: qrana
Top Score: 9,253
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Expires: 09/18/14 23:00:00
Top Group: Italiani Al Lavoro
Top Player: AdidasPete
Top Score: 15,400
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Expires: 09/11/14 23:00:00
Top Group: 7Monkeys
Top Player: Ginkai
Top Score: 9,298
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Expires: 09/04/14 23:00:00
Top Group: Go Science
Top Player: KFraser
Top Score: 8,727
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Expires: 08/28/14 23:00:00
Top Group: Gargleblasters
Top Player: Zuqq
Top Score: 8,793
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
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