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Puzzle
Expires: 09/01/16 23:00:00
3 comments
Top Group: Beta Folders
Top Player: bertro
Top Score: 23,713
Categories: Overall, Prediction
This is a follow-up puzzle for Puzzle 1268, now with NMR torsion constraints! We have some experimental data from NMR spectroscopy that tells us about some structural propensities of this protein, but we don’t have a way to turn that data into a structure. Here we've included some of these data as torsional constraints, which constrain the backbone φ- and ψ-torsions of each residue. The constraints are reflected in the Backbone subscore; look for residues with with a bad Backbone score to find areas that need improvement! Some of the torsion constraints are suggestive of α-helices and β-sheets, which have been included in the starting structure for your convenience. Players will be able to load in manual saves from Puzzle 1268 and use them as a starting point here.
Puzzle
Expires: 10/06/16 23:00:00
Top Group: Go Science
Top Player: rinze
Top Score: 8,322
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 08/31/16 18:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,453
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This cow protein, found in epithelial cells of the intestine, binds calcium as it moves from the digestive tract into the blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 09/29/16 23:00:00
Top Group: Beta Folders
Top Player: MicElephant
Top Score: 8,630
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 09/22/16 23:00:00
Top Group: Beta Folders
Top Player: Savonfou
Top Score: 8,479
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 09/15/16 23:00:00
Top Group: Void Crushers
Top Player: Madde
Top Score: 10,876
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 09/08/16 23:00:00
Top Group: Void Crushers
Top Player: Madde
Top Score: 8,956
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 09/01/16 23:00:00
Top Group: Void Crushers
Top Player: Madde
Top Score: 15,488
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 08/29/16 23:00:00
1 comment
Top Group: Beta Folders
Top Player: smilingone
Top Score: 9,839
Categories: Design, Overall
This is a basic 65 residue design puzzle with no secondary structure filter—helical bundles welcome! The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/25/16 23:00:00
17 comments
Top Group: Void Crushers
Top Player: Madde
Top Score: 12,015
Categories: Electron Density, Overall, Prediction
This is a followup to Puzzle 1249, with a new density map derived from a Foldit player solution. The solution seems to fit the data, but needs some refinement! Players may load in solutions from Puzzle 1249.
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