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Puzzle
Expires: 04/16/15 23:00:00
Top Group: SETIKAH@KOREA
Top Player: MagneticHammer
Top Score: 13,717
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 03/12/15 11:00:00
Top Group: Herobrine's Army
Top Player: HerobrinesArmy
Top Score: 9,996
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is able to absorb light and use the energy to transfer chloride ions across the cell membrane. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 03/10/15 23:00:00
4 comments
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 15,418
Categories: Design, Overall, Symmetry
See if you can improve this Foldit player-designed protein! The starting structure is a Scientist-Shared solution designed by viosca in Puzzle 1052. We don't want players to stray too far from the initial design, so there's an Exploration filter to keep solutions close to the starting structure. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 03/09/15 23:00:00
4 comments
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 15,071
Categories: Design, Overall, Symmetry
See if you can improve this Foldit player-designed protein! The starting structure is a Scientist-Shared solution designed by Bletchley Park, mimi, and spvincent in Puzzle 1052. We don't want players to stray too far from the initial design, so there's an Exploration filter to keep solutions close to the starting structure. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 03/12/15 23:00:00
Top Group: LEC Biochem 2015
Top Player: Aoth11
Top Score: 9,083
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 03/19/15 23:00:00
Top Group: SETI.Germany
Top Player: zeroblue
Top Score: 11,157
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 03/26/15 23:00:00
Top Group: Russian team
Top Player: zeroblue
Top Score: 8,755
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 04/02/15 23:00:00
Top Group: Gargleblasters
Top Player: zeroblue
Top Score: 8,644
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 04/09/15 23:00:00
Top Group: SETI.Germany
Top Player: Ernst Zundel
Top Score: 9,160
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 03/06/15 07:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,123
Categories: Design, Overall
Like Puzzle 1048, this puzzle is aimed at designing short peptides that fold into stable structures, now with an emphasis on designed sheets! See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe