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Puzzle
Expires: 10/21/14 19:00:00
2 comments
Top Group: Gargleblasters
Top Player: Zuqq
Top Score: 8,532
Categories: Overall, Prediction
In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Puzzle
Expires: 10/21/14 19:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,287
Categories: Design, Overall
In natural proteins, different amino acids show different propensities for forming secondary structures like alpha helices and beta strands. This puzzle includes a new SS Design filter that restricts the use of GLY residues in helices and sheets. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 10/21/14 19:00:00
Top Group: Go Science
Top Player: gloverd
Top Score: 9,960
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 11/20/14 23:00:00
Top Group: Structuralists
Top Player: atlas100
Top Score: 8,631
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 11/13/14 23:00:00
Top Group: Protein Pirates
Top Player: BlackyAlex
Top Score: 10,801
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 11/06/14 23:00:00
Top Group: Penn State Biomolecular Engineers
Top Player: qwertyui
Top Score: 9,286
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 11/27/14 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: pogiaron
Top Score: 8,634
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 10/23/14 23:00:00
Top Group: Italiani Al Lavoro
Top Player: Italick
Top Score: 9,139
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 10/30/14 23:00:00
Top Group: Go Science
Top Player: ChrissyH
Top Score: 15,777
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 10/16/14 23:00:00
1 comment
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 9,450
Categories: Overall, Prediction
In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe