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Puzzle
Expires: 02/27/17 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: phi16
Top Score: 9,173
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expires: 02/24/17 18:00:00
2 comments
Top Group: Anthropic Dreams
Top Player: tokens
Top Score: 11,715
Categories: Electron Density, Overall, Prediction
This is a repost of Puzzle 1340, now with an electron density map! This protein is secreted at the site of inflammation, recruiting monocytes and T cells to help fight an infection. This protein contains four cysteine residues that oxidize to form two disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players may load in solutions from Puzzle 1340.
Puzzle
Expires: 02/23/17 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,207
Categories: Design, Overall
The Ideal Loop Filter is back, but we've made some changes to encourage more proline residues. The Blueprint panel is still available, which can be accessed from the Actions menu (or the Main menu in Selection Interface). Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 03/30/17 23:00:00
Top Group: Natural Abilities
Top Player: techbites457
Top Score: 13,891
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 03/23/17 23:00:00
1 comment
Top Group: Biochemistry 315 2017
Top Player: 19036701_Engelke
Top Score: 9,221
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 03/16/17 23:00:00
1 comment
Top Group: Penn State Biomolecular Engineers
Top Player: Ahmed Badreldin
Top Score: 8,662
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 03/09/17 23:00:00
Top Group: HCC BIOL121 S2017
Top Player: iankhcc2017
Top Score: 8,699
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 03/02/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Soggy Doglog
Top Score: 11,008
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 02/23/17 23:00:00
Top Group: Biochemistry 315 2017
Top Player: 18339697_Havenga
Top Score: 9,213
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 02/20/17 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,078
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe