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Puzzle
Expires: 07/09/15 23:00:00
Top Group: Anthropic Dreams
Top Player: jordanbertasso
Top Score: 14,428
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 06/02/15 23:00:00
1 comment
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 10,377
Categories: Design, Overall
This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 06/01/15 11:00:00
Top Group: Beta Folders
Top Player: bertro
Top Score: 9,142
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small peptide was discovered in platypus venom—a rare instance of mammalian-produced venom, although this peptide appears similar to more widespread antimicrobials. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 05/29/15 23:00:00
Top Group: Go Science
Top Player: gloverd
Top Score: 11,522
Categories: Electron Density, Overall, Prediction
Scientists have had difficulty solving the structure of this bacterial enzyme, which participates in the synthesis of certain antimicrobial compounds. Players folded the N-terminal half of the protein previously in Puzzle 1088; in this puzzle we'll focus on the C-terminal half of the protein. The starting solution is based on the structure of a homologous protein. See if you can find a solution that better fits the density!
Puzzle
Expires: 07/02/15 23:00:00
Top Group: Gargleblasters
Top Player: dizzywings
Top Score: 8,969
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 06/25/15 23:00:00
Top Group: Anthropic Dreams
Top Player: mdmorella
Top Score: 8,626
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 06/18/15 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Desnouck Maarten
Top Score: 8,662
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 06/11/15 23:00:00
Top Group: Anthropic Dreams
Top Player: Cyberkashi
Top Score: 11,077
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 06/04/15 23:00:00
Top Group: APS2 - 2015
Top Player: jordanbertasso
Top Score: 9,078
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 05/26/15 23:00:00
5 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,663
Categories: Design, Overall, Symmetry
This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe