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Puzzle
Expires: 01/04/18 23:00:00
Top Group: Go Science
Top Player: ycq
Top Score: 7,929
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 11/25/17 03:00:00
Top Group: Go Science
Top Player: toshiue
Top Score: 9,284
Categories: Experimental
This protein is involved in transcription regulation and gene expression. It is also associated with both colorectal and liver cancer. In this experimental puzzle you will have 250 moves at your disposal. Once you use them up, you can reset and try something else!
Puzzle
Expires: 11/27/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Susume
Top Score: 9,932
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expires: 12/28/17 23:00:00
Top Group: STME 1903
Top Player: A Manatee
Top Score: 8,638
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expires: 11/29/17 23:00:00
1 comment
Top Group: Go Science
Top Player: Hollinas
Top Score: 22,784
Categories: Design, Overall
This is the third puzzle of our Aflatoxin Challenge, with the aflatoxin ligand now in a different orientation in the enzyme binding pocket. Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone and mutate the residue sidechains. To encourage interactions with the ligand, all ligand scores are doubled. Previous Aflatoxin Challenge designs are incompatible with this puzzle, so players will not be able to load work from previous puzzles.
Puzzle
Expires: 12/21/17 23:00:00
Top Group: Gargleblasters
Top Player: rezaefar
Top Score: 10,788
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 12/14/17 23:00:00
Top Group: Go Science
Top Player: Azukay
Top Score: 8,946
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 12/07/17 23:00:00
2 comments
Top Group: Go Science
Top Player: CanWeFoldItBetter
Top Score: 14,821
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 11/30/17 23:00:00
Top Group:
Top Player: RylandGomez
Top Score: 9,225
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.

Closed

Puzzle
Expired: 11/21/17 03:00:00
1 comment
Top Group: Go Science
Top Player: Azukay
Top Score: 9,446
Categories: Experimental
This protein is involved in transcription regulation and gene expression. It is also associated with both colorectal and liver cancer.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons