puzzle picture
Beginner Puzzle (<150): Docking Design
Status: Closed


Name: Beginner Puzzle (<150): Docking Design
Status: Closed
Created: 01/27/2014
Points: 100
Expired: 11/06/2014 - 23:00
Difficulty: Beginner
Description: We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.


If you are new to Foldit, here are detailed instructions to get you started:

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:
- Lonely Sheets,
- Lock and Lower,
- Rebuild,
- Structure and Rebuild,
- Movin' Along,
- Control over Clashing,
- Intro to Design,
- Swappin' Sidechains,
- Mass Mutate,
- Insertion and Deletion

before starting this puzzle.

Categories: Beginner

Top Groups

1Penn State Biomolecular Engineers9,286100
2Rice Biochemistry9,23187
3Protein Pirates9,20074
5Anthropic Dreams9,18654

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Joined: 10/07/2012
Groups: None
Scoring Change?

Is it just me or did the scoring on this change when the program was last updated? I had a score of 9148 saved, but when I opened it the score came in at 8818.

Joined: 10/08/2014
Groups: None
Scoring Change?

Same here. My score was 9,196 a couple days ago. Now I can't get back for the life of me. My best is now 8,928.7

Joined: 10/28/2014
Groups: DCC Folders
to helix or not to helix

Does the fragment have to be a helix? The instructions suggested that any amino acid could be mutated on the helix. I didn't think to try explore alternate loops until a couple days ago.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons