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909: Bonus CASP11 T0787 HIV-1 Env Symmetry Puzzle
Status: Closed


Name: 909: Bonus CASP11 T0787 HIV-1 Env Symmetry Puzzle
Status: Closed
Created: 06/05/2014
Points: 100
Expired: 06/10/2014 - 19:00
Difficulty: Advanced
Description: The CASP organizers have told us that this HIV-1 Env protein is a trimer, so we are posting a Bonus Round for T0787 as a symmetric trimer! We've provided you with a RosettaServer model to start with. More info in the puzzle comments about different possible folds.
Categories: CASP11, Overall, Prediction, Symmetry

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beta_helix's picture
User offline. Last seen 2 weeks 4 days ago. Offline
Joined: 05/09/2008
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Alternative packing arrangements for this complex:

We provided you with Model 1 predicted by Robetta, but you can see that Robetta Models 3-5 also formed a trimer, but they are arranged differently:


Feel free to use those packing arrangements as inspirations for your own!

NOTE the short deadline on this Bonus CASP11 Puzzle, due to Target T0787 being due early on June 11th.

More information about this CASP Target:
"CASP targets T0787 (gp41) and T0788 (gp120) are two parts of the HIV-1 Env complex, comprising three gp120 subunits and three gp41 subunits."

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons