would like to understand a play.as am a pysician of cancer and would like to make a new discovery by tis play..could any one help me ?
As this one is a small dimer why not post it as a dimer? It is small enough for us, and models like number 4 make no sense to explore now.
The CASP11 website says this is a dimer, and it is a very small puzzle. Requesting posted as a dimer, with solutions loadable from previous rounds.
Thank you!
This could be an interesting target for a symmetric puzzle, but we should keep in mind that the dimer may not be symmetric. Symmetry is indeed very common in natural protein complexes, but there are plenty of proteins that form non-symmetric oligomers.
This would make a very interesting experiment.
Post it as an symmetric dimer and post it as a free dimer.
Also: are the WeFold solutions based on dimer solutions or only on monomers?
And I have the following question:
If it is a non-symmetric dimer I am wondering how the CASP organizors can evaluate how good a solution is.
I totally agree with Timo! I'd like to see it as a symmetric and a non-symmetric dimer :)
I'd like to see it as a free dimer, too. The puzzle as it stands is strange and uninteresting, but I think it'd be much better with two pieces so the interactions between them are easier to see.
a 5 seg loop with all glyceine that could be placed where we want and this loop could act as a buffer for phobes in the real protein. just something to alter the way the protein responds so that we don't bury phobes that look like a bonding site to another protein. i don't know, i'm just spitballing here.
Here is the sequence logo predicted by the SAM server:
H = helix
E = sheet
C = loop (or coil)
The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.
Note that these secondary structure predictions are not necessarily present in the server model that has been provided in the puzzle.
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If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.