puzzle picture
801: Abeta Binder Redesign
Status: Closed

Summary

Name: 801: Abeta Binder Redesign
Status: Closed
Created: 10/28/2013
Points: 0
Expired: 11/04/2013 - 23:00
Difficulty: Intermediate
Description: In this puzzle, you can redesign a protein that was found to bind Abeta, a peptide associated with Alzheimer's disease. See the blog post about this for more information. The Abeta protein backbone is frozen in this puzzle. The binding protein consists of two chains, in which you can mutate all but several loop residues. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. Help us design a tighter-binding protein for Abeta!
Categories:

Top Groups

RankGroupScorePoints
1Contenders13,4780
2Beta Folders13,3300
3Go Science13,3220
4Void Crushers13,3160
5Anthropic Dreams13,3060

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

Joined: 06/24/2008
Groups: Void Crushers
Dumb Question

The two different Exploration multiples are for the two different parts? Just making sure I understand what is there.

bkoep's picture
User offline. Last seen 14 hours 39 min ago. Offline
Joined: 11/15/2012
Groups: None
Correct

The starting model of the binding protein is a dimer of two nearly-identical chains. There is an RMSD filter for each chain of the binding protein.

I apologize that we could not label each filter for its corresponding chain.

wisky's picture
User offline. Last seen 8 weeks 3 days ago. Offline
Joined: 07/13/2011
ARGININES EVERYWHERE

Seems the only way to get a decent score on this puzzle is to place arginines all across the outside of the helices. Something just seems off about it.

bkoep's picture
User offline. Last seen 14 hours 39 min ago. Offline
Joined: 11/15/2012
Groups: None
Puzzle reposted

Thanks for commenting about this. There was a problem with the score function in this puzzle, so it has been closed and reposted as Puzzle 801b.

The reposted puzzle can be found here:
http://fold.it/portal/node/996193

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons