puzzle picture
769: Quick Loop Redesign
Status: Closed


Name: 769: Quick Loop Redesign
Status: Closed
Created: 08/27/2013
Points: 100
Expired: 08/30/2013 - 20:00
Difficulty: Intermediate
Description: This is a puzzle where you can redesign part of a player-designed protein. This is the subunit of a symmetric tetramer designed by jamiexq, karstenw, and markm457 for Puzzle 725. Baker lab simulations suggest that one of the beta strands is unlikely to form because the loops on either end prefer different conformations. Help us redesign these loops to find a solution that will fold up properly! You have one additional residue that you can insert in the protein, but most of the protein is frozen in this puzzle. This puzzle will only be active for three days!
Categories: Design, Overall

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons