puzzle picture
735: Player-Solution Loop Redesign: Round 2
Status: Closed


Name: 735: Player-Solution Loop Redesign: Round 2
Status: Closed
Created: 06/24/2013
Points: 100
Expired: 07/02/2013 - 17:00
Difficulty: Intermediate
Description: This is a puzzle where you can redesign part of a player-designed protein. Galaxie's top-scoring solution from Puzzle 720 shows promise in the Baker Lab's folding simulations, but one loop seems to be a little troublesome. In Puzzle 734, you were allowed to design just this short loop, but now you can redesign an entire helix. Like the last puzzle, you can insert up to four residues and mutate residues near the helix, but the rest of the protein is frozen. The scientists at the Baker Lab like the general placement of this helix, so there is also an RMSD condition for the helix residues. You can load in solutions from Puzzle 734.
Categories: Design, Overall

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons