731b: Unsolved Chicken Anemia Virus Protein

Summary

Name:

Status:

Closed

Created:

06/19/2013

Points:

150

Difficulty:

Intermediate

Description:

Apoptin is a viral protein of special interest because it targets cancer cells and causes apoptosis. Solving this protein structure would greatly advance research into apoptin’s functionality and development as a method to treat cancer. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. So that you have plenty of time to try out each model, this puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

Categories:

Overall, Prediction

Rank

Group

Score

Points

Anthropic Dreams

10,803

150

Contenders

10,727

124

Void Crushers

10,706

101

Gargleblasters

10,682

Beta Folders

10,630

Rank

Player

Group

Score

Points

Galaxie 1 9

Anthropic Dreams

10,803

150

jamiexq 4 64

Anthropic Dreams

10,793

148

phi16 15 62

Anthropic Dreams

10,791

146

markm457 130 3274

Anthropic Dreams

10,791

144

dflear 123 982

Anthropic Dreams

10,791

141

Rank

Player

Group

Score

Points

marie_s 130 3274

10,862

150

jamiexq 4 64

Anthropic Dreams

10,797

148

mimi 13 22

Contenders

10,727

146

gramps 130 3274

Anthropic Dreams

10,708

144

Madde 70 12

Void Crushers

10,706

141

Wed, 06/19/2013 - 23:54

beta_helix 130 3274

Offline

Joined: 05/09/2008

Groups: None

This is the reposted version of 731

We've added the Disulfide Count Score Filter to Puzzle 731.

The new Disulfide Count Score Filter gives you a bonus for forming bridges. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them.

You will be able to load in your manual saves from 731 into this puzzle. If you did not manually save a solution in puzzle 731, you can go back to 731, manually save it, and the solution should appear in your manual saves for this puzzle, 731b.

Here is the original puzzle, with the motivation for why we reposted it:
http://fold.it/portal/node/995342#comment-23494

Sat, 06/22/2013 - 01:36

brow42 130 79

Offline

Joined: 09/19/2011

Groups: None

use of disulfide filter

If you enable the filter on a puzzle, that means the players will try to make as many bridges as they can. What if some don't exist, or exist to another molecule not in the puzzle? A 100 point bonus can cover up a lot of unnatural contortions to make that bridge. I'd rather not have the filter enabled, unless the scientists are certain that every cysteine is part of a bridge, like in a knot.

Sat, 06/22/2013 - 16:38

beta_helix 130 3274

Offline

Joined: 05/09/2008

Groups: None

We reposted this based on what the Scientists told us

You will not get an extra bonus for forming more bridges than they recommend.
We are able to set the bonus for the range of bridges we want (and in fact can penalize for too many bridges if we need to).
_________________________________

The Worcester Polytechnic Institute Scientists have also answered another question in the feedback:
http://fold.it/portal/node/995388