725: Quick 60 Residue Tetramer Redesign

Status: Closed

Summary

Name:	725: Quick 60 Residue Tetramer Redesign
Status:	Closed
Created:	06/04/2013
Points:	100
Expired:	06/09/2013 - 02:00
Difficulty:	Intermediate
Description:	This is a 60 residue symmetric tetramer design puzzle. The starting structure is a solution to Puzzle 691 that was shared with us by MurloW. The scientists at the Baker Lab like the topology of this solution, but simulations predict that this amino acid sequence will not fold up properly from an extended chain. Help us redesign this solution into a folding protein! The ResidueIE and "Core Exists" filters will make sure PHY, TYR, and TRP residues are scoring well, and that the protein core includes at least 35% of the residues. We look forward to seeing your mutations to this fold, although you are free to redesign the entire protein in this puzzle.
Categories:	Design, Overall, Symmetry

Top Groups

Rank	Group	Score	Points
1	Beta Folders	16,404	100
2	Contenders	16,115	83
3	L'Alliance Francophone	15,805	68
4	Anthropic Dreams	15,739	55
5	Void Crushers	15,730	44

Show all >

Top Evolvers

Rank	Player	Group	Score	Points
1	Bruno Kestemont 3 2	Beta Folders	16,404	100
2	Angus 74 1534	Beta Folders	16,387	98
3	smilingone 44 191	Beta Folders	16,376	96
4	Bletchley Park 9 9	Contenders	16,115	94
5	gitwut 74 156	Contenders	16,115	91

Show all >

Top Soloists

Rank	Player	Group	Score	Points
1	bertro 58 396	Beta Folders	16,234	100
2	Bletchley Park 9 9	Contenders	16,105	98
3	Museka 74 305	L'Alliance Francophone	15,805	96
4	pvc78 74 201	Beta Folders	15,766	94
5	Timo van&n... 74 52	Void Crushers	15,730	91

Show all >

Need this puzzle? Log in to download.

Comments

Wed, 06/05/2013 - 01:44

BootsMcGraw 10 7

Offline

Joined: 12/06/2008

Groups: Contenders

No wiggle.

Wiggle doesn't work, even with the "Disable Slow Filters" box checked and the CI pulled way down. Neither does Shake. Mutate barely works.

If anyone else is experiencing this, I'll file a trouble ticket.

Wed, 06/05/2013 - 20:16

drumpeter18yrs9yrs 74 86

Offline

Joined: 02/08/2012

Groups: None

I agree

there are some problems with wiggle. shake seems to be slow. however, wiggling sidechains seems to work the best. If there are a lot of bands, wiggle backbone does work a little bit; but still, not very well. if you select sheets and helices one by one, mutate works fairly fast.

Wed, 06/05/2013 - 13:39

Bruno Kestemont 3 2

Offline

Joined: 09/24/2012

Groups: Go Science

Everything is ok for me. May be restart all clients ?


	User login Username: * Password: * Create new account Request new password

Download links:


Windows (7/8/10)	OSX (10.12 or later)	Linux (64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.


	Social Media


	Search Only search fold.it


	Click here to read Foldit's statement on the Black Lives Matter movement.


	Other Games: Mozak

Recommend Foldit


	Topics
	I absolutely hate the new interface Happy few Gold players in History Exciting time for protein design Foldit Newsletters Allow tweaks to foldit behavior with files in linux to meet the requirement of package managers


	Top New Users artghat James Barrie elainec SemperRabbit Tony Young

Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons