The new "Upload for Scientists" button
We are very excited about the new "Upload for Scientists" button that has been added to Foldit.
As mentioned in a recent blogpost we needed a way for you to send us your favorite Foldit solutions, since those might not be your top-scoring ones.
We wanted to let you know that we haven't only been looking at your top-scoring design solutions this whole time.
We've been clustering all your designs to find the top-scoring solutions for the different topologies you have come up with.
We start with the top-scoring Foldit model and then filter all the remaining solutions, only keeping those that are more than a certain cutoff in RMSD from the starting structure. This results in the top-scoring structure being the only representative model for that particular topology. We then take the next-best scoring Foldit model (that hasn't already been filtered out) and do the same thing… and so on.
In the end, what we are left with are different folds (how different depends on the cutoff we use, we usually try a bunch of different values for a specific Foldit puzzle) but each representative fold is the top-scoring Foldit solution for that shape.
That is how we selected which designs from Puzzle 691 to test experimentally in the lab (see David Baker's blogpost about this), in addition to the ones that you sent to us directly. We will keep you posted on those results soon!
We plan to setup a means of rewarding players who send us useful solutions that are either tested in lab, or used as starting models for subsequent design Puzzles (such as Steven Pletsch's solution that was used as the start for Puzzle 708).
For now, please start using the new "Upload for Scientists" button. For each Foldit puzzle you are able to upload your THREE favorite solutions.
We are excited to see what you send us, particularly for the new Flu Puzzle (718) after chatting with Aaron at last week's Scientist Chat to see what it is he is looking for. If you missed the chat, you can read the transcript here.