puzzle picture
702: Second Sepsis Puzzle Round 2
Status: Closed


Name: 702: Second Sepsis Puzzle Round 2
Status: Closed
Created: 04/17/2013
Points: 100
Expired: 04/25/2013 - 16:00
Difficulty: Intermediate
Description: This is Round 2 for Puzzle 697. You will be able to load in your manual saves from 697 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch! NOTE: If you did not manually save a solution in puzzle 697, you can go back to 697, manually save it, and the solution should appear in your manual saves for this puzzle. PLEASE NOTICE that Valine 32 can be mutated!
Categories: Design, Overall

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5Another Hour Another Point9,56142

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User offline. Last seen 2 days 11 hours ago. Offline
Joined: 05/09/2008
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Additional info about this puzzle:

Please read the Blog Entry about this puzzle: http://fold.it/portal/node/994592

and here is a link to the Scientist Chat about it:

PLEASE NOTE that Valine 32 can be mutated!

If you are new to Foldit, make sure you have completed Intro Puzzles 7-1 through 7-4 before trying this puzzle.

This puzzle has the ResidueIE filter on (to try to ensure that PHE, TYR, and TRP residues are scoring properly) and we've increased the Ligand Score by a factor of 10 to promote interactions with the sugar.

Tip: To see the parts of the sugar that you can bond to, check Show bonds (non-protein) and Show bondable atoms in the View menu. Make sure Show bonds (loop) and Show bonds (sidechain) are also on. Blue can bond to red, and purple can bond to either blue or red.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons