puzzle picture
672: Starting Asymmetry
Status: Closed


Name: 672: Starting Asymmetry
Status: Closed
Created: 01/25/2013
Points: 100
Expired: 02/02/2013 - 23:00
Difficulty: Intermediate
Description: This puzzle starts out asymmetric but needs to be made symmetric. You can move one half of it to make it match the other half, and fit them together!
Categories: Overall

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Joined: 12/06/2008
Groups: Contenders
Half the puzzle is frozen!

We're supposed to make the two pieces symmetric, but the frozen piece is all stretched out. That's not right. Y'all want us to make both halves stretched out??

Joined: 11/10/2007
Groups: Window Group
It's more the other way

It's more the other way around - change the unfrozen piece to match the frozen piece.

Joined: 09/21/2011
Groups: Void Crushers
It took me 45 minutes to

It took me 45 minutes to write a simple script to copy the structure.
Simple, copy the distance from segment i+50,j+50 to seg i,j. We can make a band between i+50 and j+50 and use the bandlength to do just that.

Joined: 05/19/2009
Groups: Contenders
How does the scoring function

How does the scoring function guide us here ? how well the unfrozen piece matches the frozen one AND how they interact ? Or is this just about how well copied the whole thing is and how nice the symmetry ends up ?

Joined: 05/19/2009
Groups: Contenders
And if I may auggest; If this

And if I may auggest; If this is anout what the best symmetric organization is, it would help to receive both parts frozen and idential so we do not have to waste our time trying to make an identical copy.

Joined: 01/28/2013
Groups: None
not sure how to start playing

not sure how to start playing

Joined: 05/19/2009
Groups: Contenders
Please explain science objective here.

I would like to reiterate my question. What is the science goal to achieve ? Are we to keep the shape frozen yes or no ?

If we first need to COPY the existing shape, there is no point in KEEPING that copy if the structure is not to be frozen afterwards in order not to loose that shape. If we can unfreeze it, there is no point in COPYING the shape in the first place.

This information will greatly impact the approach. Without this information the exercise is pointless as it will only be a race towards points, guided by an undisclosed scoring function.

jflat06's picture
User offline. Last seen 1 hour 45 min ago. Offline
Joined: 09/29/2010
Groups: Window Group

The objective is to fold the non-locked copy to match the locked one, and move the unlocked copy into what you believe is the best symmetric orientation. This protein is symmetric in nature, and this is a sort of pseudo-QTTN and docking problem.

Joined: 05/28/2012
Is this part of a larger protein

There seems to be a lot of funky stuff going on in this puzzle. I can make it symmetric perfectly, dock it and get at most 3700-4100. (depending on disulfide bonding.) it seems that all the side chain scores on the locked protein as well as on the unlocked are way to low to just be by itself. i think this is severely hindering the folding and making it impossible to make it symmetric and score good. our top score for our group is so dis-formed and far from symmetric that its not even funny. we either need the entire protein if there is one, or some sort of bonus/penalty for not following symmetry.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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