670 crash in disulfide scoring function

Case number:845829-994358
Topic:Crash/Hang
Opened by:Bletchley Park
Status:Closed
Type:Bug
Opened on:Sunday, January 20, 2013 - 15:44
Last modified:Wednesday, January 30, 2013 - 22:44

Devprev:
2013-01-15-53170-win_x86-devprev

basic.io.database: Database file opened: scoring/score_functions/disulfides/fa_SS_distance_score
core.conformation.Conformation: Found disulfide between residues 14 74
core.conformation.Conformation: current variant for 14 CYS
core.conformation.Conformation: current variant for 74 CYS
core.conformation.Conformation: current variant for 14 CYD
core.conformation.Conformation: current variant for 74 CYD
core.conformation.Conformation: Found disulfide between residues 44 104
core.conformation.Conformation: current variant for 44 CYS
core.conformation.Conformation: current variant for 104 CYS
core.conformation.Conformation: current variant for 44 CYD
core.conformation.Conformation: current variant for 104 CYD

UNHANDLED EXCEPTION
1: library_main +19639412 bytes (no line)
2: library_main +4472499 bytes (no line)
3: library_main +1261013 bytes (no line)
4: library_main +3815325 bytes (no line)
5: library_main +4987229 bytes (no line)
6: library_main +4118766 bytes (no line)
7: library_main +3514614 bytes (no line)
8: library_main +4116926 bytes (no line)
9: library_main +1436301 bytes (no line)
10: library_main +1490825 bytes (no line)
11: library_main +28021976 bytes (no line)
12: library_main +28033267 bytes (no line)
13: library_main +28022094 bytes (no line)
14: library_main +28022505 bytes (no line)
15: library_main +4210444 bytes (no line)
16: library_main +4205678 bytes (no line)
17: library_main +4254990 bytes (no line)
18: library_main +4258134 bytes (no line)
19: BaseThreadInitThunk +18 bytes (no line)
20: RtlInitializeExceptionChain +99 bytes (no line)
21: RtlInitializeExceptionChain +54 bytes (no line)

From windows 7 64 professional:
Problem signature:
Problem Event Name: APPCRASH
Application Name: Foldit.exe
Application Version: 0.0.0.0
Application Timestamp: 4e761405
Fault Module Name: game_library.dll
Fault Module Version: 0.0.0.0
Fault Module Timestamp: 50f5ea8a
Exception Code: c0000005
Exception Offset: 012bbc79
OS Version: 6.1.7601.2.1.0.256.48
Locale ID: 1043
Additional Information 1: 0a9e
Additional Information 2: 0a9e372d3b4ad19135b953a78882e789
Additional Information 3: 0a9e
Additional Information 4: 0a9e372d3b4ad19135b953a78882e789

(Sun, 01/20/2013 - 15:44  |  6 comments)


Joined: 09/21/2011
Groups: Void Crushers

I had the same error, but in my case it looks like multiple bridges to 1 segment. I was running Mutate Combo. The part where it only mutates 1 segment at a time. Looking at the last position (after a restart) I do not see any cystines so I think it is very strange that 74 and 76 are both considered to be a cys. Hope this helps to locate the problem.

14 to 74 and 14 to 76.

core.pack.interaction_graph.interaction_graph_factory: Instantiating DensePDInteractionGraph
core.pack.pack_rotamers: built 2 rotamers at 1 positions.
core.pack.pack_rotamers: IG: 504 bytes
core.conformation.symmetry.Conformation: Found disulfide between residues 14 76
core.conformation.symmetry.Conformation: current variant for 14 CYS
core.conformation.symmetry.Conformation: current variant for 76 CYS
core.conformation.symmetry.Conformation: current variant for 14 CYD
core.conformation.symmetry.Conformation: current variant for 76 CYD
basic.io.database: Database file opened: scoring/score_functions/disulfides/fa_SS_distance_score
core.conformation.Conformation: Found disulfide between residues 14 74
core.conformation.Conformation: current variant for 14 CYS
core.conformation.Conformation: current variant for 74 CYS
core.conformation.Conformation: current variant for 14 CYD
core.conformation.Conformation: current variant for 74 CYD
core.conformation.Conformation: Found disulfide between residues 44 104
core.conformation.Conformation: current variant for 44 CYS
core.conformation.Conformation: current variant for 104 CYS
core.conformation.Conformation: current variant for 44 CYD
core.conformation.Conformation: current variant for 104 CYD
delta_score: -1198.42
Playing sound: 0
core.pack.interaction_graph.interaction_graph_factory: Instantiating DensePDInteractionGraph
core.pack.pack_rotamers: built 93 rotamers at 5 positions.
core.pack.pack_rotamers: IG: 13036 bytes
core.conformation.symmetry.Conformation: Found disulfide between residues 14 76
core.conformation.symmetry.Conformation: current variant for 14 CYD
core.conformation.symmetry.Conformation: current variant for 76 CYD
core.conformation.symmetry.Conformation: current variant for 14 CYD
core.conformation.symmetry.Conformation: current variant for 76 CYD
core.conformation.Conformation: Found disulfide between residues 14 74
core.conformation.Conformation: current variant for 14 CYS
core.conformation.Conformation: current variant for 74 CYS
core.conformation.Conformation: current variant for 14 CYD
core.conformation.Conformation: current variant for 74 CYD
core.conformation.Conformation: Found disulfide between residues 44 104
core.conformation.Conformation: current variant for 44 CYS
core.conformation.Conformation: current variant for 104 CYS
core.conformation.Conformation: current variant for 44 CYD
core.conformation.Conformation: current variant for 104 CYD

UNHANDLED EXCEPTION
1: library_main +19641742 bytes (no line)
2: library_main +4472467 bytes (no line)
3: library_main +1261013 bytes (no line)
4: library_main +3815325 bytes (no line)
5: library_main +4722819 bytes (no line)
6: library_main +4254990 bytes (no line)
7: library_main +4258134 bytes (no line)
8: BaseThreadInitThunk +18 bytes (no line)
9: RtlInitializeExceptionChain +99 bytes (no line)
10: RtlInitializeExceptionChain +54 bytes (no line)

katfish's picture
User offline. Last seen 4 years 49 weeks ago. Offline
Joined: 01/09/2013

Thank you for your report, Bletchley Park and Timo. We are currently working on a fix for this.

Susume's picture
User offline. Last seen 2 days 21 hours ago. Offline
Joined: 10/02/2011

Client locked up (not responding, Windows error) on 670 during script Tvdl enhanced DRW with no mutating. Log says it found disulfide bonds at segments 6 (which is the only actual CYS currently in the protein) and 36, 66, 96 and 99 (none of which exist). Latest devprev, Win7 64.

Autosaved puzzles/0000994302/0000341210/s2_waffle/autosave.ir_solution.
Autosaved puzzles/0000994302/0000341210/s2_waffle/autosave-best.ir_solution.
Autosaved puzzles/0000994302/0000341210/s2_waffle/autosave-recentbest.ir_solution.
Autosaved puzzles/0000994302/0000341210/s2_waffle/autosave-creditbest.ir_solution.
core.conformation.symmetry.Conformation: Found disulfide between residues 6 99
core.conformation.symmetry.Conformation: current variant for 6 CYS
core.conformation.symmetry.Conformation: current variant for 99 CYS
core.conformation.symmetry.Conformation: current variant for 6 CYD
core.conformation.symmetry.Conformation: current variant for 99 CYD
basic.io.database: Database file opened: scoring/score_functions/disulfides/fa_SS_distance_score
core.conformation.Conformation: Found disulfide between residues 6 96
core.conformation.Conformation: current variant for 6 CYS
core.conformation.Conformation: current variant for 96 CYS
core.conformation.Conformation: current variant for 6 CYD
core.conformation.Conformation: current variant for 96 CYD
core.conformation.Conformation: Found disulfide between residues 36 66
core.conformation.Conformation: current variant for 36 CYS
core.conformation.Conformation: current variant for 66 CYS
core.conformation.Conformation: current variant for 36 CYD
core.conformation.Conformation: current variant for 66 CYD
core.conformation.symmetry.Conformation: Found disulfide between residues 6 99
core.conformation.symmetry.Conformation: current variant for 6 CYD
core.conformation.symmetry.Conformation: current variant for 99 CYD
core.conformation.symmetry.Conformation: current variant for 6 CYD
core.conformation.symmetry.Conformation: current variant for 99 CYD
core.conformation.Conformation: Found disulfide between residues 6 96
core.conformation.Conformation: current variant for 6 CYS
core.conformation.Conformation: current variant for 96 CYS
core.conformation.Conformation: current variant for 6 CYD
core.conformation.Conformation: current variant for 96 CYD
core.conformation.Conformation: Found disulfide between residues 36 66
core.conformation.Conformation: current variant for 36 CYS
core.conformation.Conformation: current variant for 66 CYS
core.conformation.Conformation: current variant for 36 CYD
core.conformation.Conformation: current variant for 66 CYD

UNHANDLED EXCEPTION
1: library_main +19641742 bytes (no line)
2: library_main +4472467 bytes (no line)
3: library_main +1261013 bytes (no line)
4: library_main +3815325 bytes (no line)
5: library_main +4727586 bytes (no line)
6: library_main +4692605 bytes (no line)
7: library_main +4696335 bytes (no line)
8: library_main +17290762 bytes (no line)
9: library_main +17292464 bytes (no line)
10: library_main +18030510 bytes (no line)
11: library_main +18040757 bytes (no line)
12: library_main +17322087 bytes (no line)
13: library_main +17290005 bytes (no line)
14: library_main +4733591 bytes (no line)
15: library_main +4254990 bytes (no line)
16: library_main +4258134 bytes (no line)
17: BaseThreadInitThunk +18 bytes (no line)
18: RtlInitializeExceptionChain +99 bytes (no line)
19: RtlInitializeExceptionChain +54 bytes (no line)

Joined: 09/21/2011
Groups: Void Crushers

Susume, logic tells me that 36, 66, 96 are on the symmetric parts. 99 is the culprit I think.

Joined: 11/10/2007
Groups: Window Group
Status: Open » Closed

We've made a number of fixes related to crashes with disulfides, particularly in symmetry puzzles. They will go out in an update soon.

Joined: 11/10/2007
Groups: Window Group
Status: Closed » Closed

This has been released in the recent update.

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