puzzle picture
669: De-novo Freestyle 18
Status: Closed

Summary

Name: 669: De-novo Freestyle 18
Status: Closed
Created: 01/14/2013
Points: 100
Expired: 01/22/2013 - 20:00
Difficulty: Advanced
Description: We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Categories: Overall, Prediction

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Comments

beta_helix's picture
User offline. Last seen 4 days 8 hours ago. Offline
Joined: 05/09/2008
Groups: None
Here are the secondary structure predictions

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 38, 63, 111 & 116 are highly predicted to be part of a sheet. However, the Valines at residues 87 & 142 are not predicted to be anything!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons