670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
|Name:||670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry|
|Expired:||02/05/2013 - 12:00|
|Description:||Puzzle 670 is a small (30 residue) symmetric tetramer design puzzle. In other words you will be working with a protein that is made up of 4 symmetric chains. Symmetry becomes complicated when you are working with more than 3 chains. Tetramers, which we learned have 4 chains, can be arranged in a ring (called "C4" symmetry). Or, they can be arranged as a dimer of dimers ("D2" or "two-by-two" symmetry - 2 dimers put together forming a total of 4 symmetric sub-units). The dimer of dimers arrangement is much more common in nature. Keep in mind that symmetric proteins rely on more than just how well-folded each chain is. They also rely on how well the chains interface together. This protein has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD.|
|Categories:||Design, Overall, Symmetry|
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