Please read the blogpost about how this puzzle could help us fight cancer: http://fold.it/portal/node/993721

Scientist Chat transcript: http://fold.it/portal/node/992895
Original Blogpost (about the Frizzled protein with the more narrow pocket): http://fold.it/portal/node/992888

We are aware of the fact that the residueIE filter complains about certain residues on the surface of the native Frizzled protein (this has been brought up before:
http://fold.it/portal/node/993602#comment-20813 ) but unfortunately the fix for this isn't in the latest update, so you'll have to ignore those for now.

This is similar to any clashes you ever find in locked regions: every player will have them and there is nothing that you can do about it, so it's best to just ignore them for now.

(But we realize that it is annoying to see those negative scores, so in the future we will try to get rid of them).