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659 (<150): Re-Return of the Tissue Regeneration Design Puzzle
Status: Closed


Name: 659 (<150): Re-Return of the Tissue Regeneration Design Puzzle
Status: Closed
Created: 12/04/2012
Points: 100
Expired: 12/15/2012 - 23:00
Difficulty: Intermediate
Description: We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments. For players with fewer than 150 global points.
Categories: Beginner

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tamirh's picture
User offline. Last seen 8 years 32 weeks ago. Offline
Joined: 05/11/2012
More info here:

This is a repost of Puzzle 571: Tissue Regeneration Design Puzzle, but with a new filter that should help with the scoring artifacts that were prevalent in that puzzle. We tried this with puzzle 633 but the ResidueIE filter was broken and this caused windows machines to crash. With the ResidueIE filter fixed, we wanted to try the puzzle again.

More background on this puzzle can be found in the original blogpost: http://fold.it/portal/node/992888

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons