puzzle picture
640: Frizzled Design Puzzle
Status: Closed

Summary

Name: 640: Frizzled Design Puzzle
Status: Closed
Created: 10/11/2012
Points: 100
Difficulty: Beginner
Description: You've seen this design puzzle before, but look more closely! The Frizzled protein occurs in a number of forms. Last time we gave you a form of Frizzled with a narrow pocket. This time we are giving you a form of Frizzled with a wider pocket. There are a couple of rules: You can mutate any residue on the helix but none on Frizzled and the small binding helix must stay in helical shape. We've also added a new filter that we call "Residue Interaction Energy". Natural proteins avoid putting Tryptophan, Phenylalanine, and Tyrosine on the surface. However, Foldit often gives a score bonus if you load up the surface of your design with Tryptophan. The Residue Interaction Energy filter helps to counteract that, helping you make better designs. Enjoy and thanks for all of your efforts!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Contenders10,118100
2Go Science10,11785
3Anthropic Dreams10,11772
4foldeRNA10,11761
5Beta Folders10,11751

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1pauldunn 37 19 Go Science10,117100
2Aubade00 120 3144  10,11799
3jamiexq 5 58 Anthropic Dreams10,11797
4bertro 36 24 foldeRNA10,11796
5pvc78 84 32  10,11794
 

Comments

Joined: 05/09/2008
Groups: None
Check out the blogpost

for more information about this puzzle:
http://fold.it/portal/node/993721

Get Started: Download
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Windows
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OSX
(Intel 10.5 or later)
Linux
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Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe