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627: 30 Residue Symmetric Dimer of Dimers Freestyle
Status: Closed
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Summary
| Name: | 627: 30 Residue Symmetric Dimer of Dimers Freestyle |
|---|---|
| Status: | Closed |
| Created: | 09/06/2012 |
| Points: | 100 |
| Difficulty: | Intermediate |
| Description: | This is a small (30 residue) symmetric tetramer design puzzle; there will be four symmetric chains to manage. Symmetry becomes more complicated past three chains; for example, tetramers can be arranged in a ring (called "C4" symmetry) or as a dimer of dimers ("D2" or "two-by-two" symmetry). The dimer of dimers is much more common in nature, so we'll be exploring that type of symmetry first. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. This dimer of dimers has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD. Stay tuned for higher-order symmetries; it only gets crazier from here! |
| Categories: | Design, Overall, Symmetry |
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