New Sepsis Design Puzzle!

Sepsis is a potentially lethal condition affecting hundreds of thousands of people every year in which a severe infection spreads into the bloodstream, leading
to multi-organ systems failure and often death. Despite years of research, clinicians are in need of new treatments for sepsis.

Research teams at the University of Washington and at the Wyss Institute for Biologically Inspired Engineering at Harvard University are developing protein-based pathogen capture reagents to be used for the removal of circulating pathogens from the blood of patients. The approach combines online gaming as a platform to introduce and improve upon innovative protein designs with state-of-the art protein manufacturing capabilities critical in translating such designs for clinical applications.

In the present Foldit challenge, we are asking you to design improved versions of a protein called Mannose-Binding Lectin (MBL).  MBL belongs to a class of proteins that act as the body’s natural first line of defense against invading pathogens, such as Salmonella and Staphylococci, by recognizing specific sugars on their surfaces.  The goal here is to use Foldit to improve MBL’s sugar binding capabilities, allowing for its potential clinical use.  You will work towards this goal by redesigning specific regions of MBL in order to increase the number and strength of protein-sugar interactions. 

At the conclusion of the challenge, the most promising Foldit designs will be manufactured and tested at the Wyss Institute in order to determine their pathogen capture capabilities, and whether they represent an improvement over natural MBL.  If the current approach of using Foldit to target pathogens proves successful, we plan to continue our effort by designing additional capture reagents.

Join us in helping to solve this important public health issue!

( Posted by  beta_helix 74 952  |  Wed, 08/29/2012 - 21:13  |  6 comments )
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Try out this puzzle here:
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locked sidechains

When you post the next stage of this puzzle, would you unlock sidechains (not mutable) so that they can move out of the way? I got big old glutamate sitting right were I want to put my backbone. It was empty space until I added segments. I'm sure it would be just as happy a little to the left. :(

P.S. Oddly, I notice this glutamate moving on wiggle, even though it is locked. Number 88.

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DARPA press release relating to the Sepsis Design Puzzle 625

8/30 '12: "Crowdsourcing Breakthrough Treatments for Blood Infections"

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Thanks for the info. It is in reality a nice and helpful piece of information. I am happy that you shared this helpful information with us. Please stay us up to date like this. Thanks for sharing.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons