puzzle picture
623: 40 Residue Symmetric Trimer Freestyle
Status: Closed


Name: 623: 40 Residue Symmetric Trimer Freestyle
Status: Closed
Created: 08/27/2012
Points: 100
Expired: 09/04/2012 - 10:00
Difficulty: Intermediate
Description: This is a small (40 residue) symmetric trimer design puzzle. We saw some very interesting structures for the related 30 residue puzzle (Puzzle 595), but ten extra residues should make this a very different challenge. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together - and a symmetric trimer can be thought of as having three 2-fold interfaces. Stay tuned for higher-order symmetries, like tetrahedra and octahedra!
Categories: Design, Overall, Symmetry

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons