puzzle picture
625: Sepsis Puzzle
Status: Closed

Summary

Name: 625: Sepsis Puzzle
Status: Closed
Created: 07/24/2012
Points: 120
Difficulty: Intermediate
Description: Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by extending a specific loop region of this protein. Please build upon this region, and extend it to make additional hydrogen bond interactions with the sugar. The best Foldit designs will then be used to generate potential pathogen capture reagents. Please read the blogpost for more info and if you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
Categories: Design, Overall

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Comments

Joined: 05/09/2008
Groups: None
START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

This puzzle is worth 120 global points!

More details about this puzzle in the blog:
http://fold.it/portal/node/993419

Susume's picture
User offline. Last seen 1 hour 40 min ago. Offline
Joined: 10/02/2011
Tip: To see the parts of the

Tip: To see the parts of the sugar that you can bond to, check Show bonds (non-protein) and Show bondable atoms in the View menu. Make sure Show bonds (loop) and Show bonds (sidechain) are also on. Blue can bond to red, and purple can bond to either blue or red.

Joined: 05/18/2008
Groups: None
see feedback

http://fold.it/portal/node/993431
thx Susume and Seth

XBane's picture
User offline. Last seen 1 year 50 weeks ago. Offline
Joined: 09/02/2012
Groups: None
subscore discrepancy

current.GetSegmentEnergySubscore(M,"bonding") does not return the same value for the ligand as the Tab key.

Joined: 11/10/2007
Groups: Window Group
Thanks for reporting the

Thanks for reporting the score discrepancy in scripting. The tab key is reporting the correct number. That has been fixed and will be part of the next update.

Angus's picture
User offline. Last seen 14 hours 54 min ago. Offline
Joined: 06/04/2008
Groups: Beta Folders
Is this puzzle closed, open

Is this puzzle closed, open or lost in-between? It's 2:13 past closing time but still shows "Active" and no points assigned.

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