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605: CASP10 Refinement Puzzle: TR710
Status: Closed
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Summary
| Name: | 605: CASP10 Refinement Puzzle: TR710 |
|---|---|
| Status: | Closed |
| Created: | 07/23/2012 |
| Points: | 100 |
| Difficulty: | Intermediate |
| Description: | This is the fifteenth CASP10 Refinement Target. We've been told that about 75% of this model matches the native, so you'll need to refine ~25% of the structure! More info in the puzzle comments. |
| Categories: | CASP, Overall, Prediction |
![](http://128.95.1.228:8000/tracking_pixel.gif?events=scAdd&f=1111&wdata={"x":12, "y":11}){kind=tracking}
Please note that the Cut Tool is available on this puzzle!
This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=188
The CASP10 organizers gave us this hint:
"Starting model GDT_TS=75."
GDT_TS=75 essentially means that 75% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test
Here is the sequence logo predicted by the SAM server:
H = helix
E = sheet
C = loop (or coil)
The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.
For example, the Valines at residues 19, 52, 85, 145 & 177 are highly predicted to be part of a helix. However, the Valines at residues 96 & 100 are not.