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604: CASP10 Refinement Puzzle: TR698
Status: Closed
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Summary
| Name: | 604: CASP10 Refinement Puzzle: TR698 |
|---|---|
| Status: | Closed |
| Created: | 07/22/2012 |
| Points: | 100 |
| Difficulty: | Intermediate |
| Description: | This is the fourteenth CASP10 Refinement Target. This model was the best server prediction for target T0698, generated by the PMS server. We've been told that ~65% of this model matches the native, so you'll need to significantly change the starting model. Luckily, they have told us which regions require special attention: residues 17-35 & 90-100. These regions are shown in Note Mode. More info in the puzzle comments. |
| Categories: | CASP, Overall, Prediction |
![](http://128.95.1.228:8000/tracking_pixel.gif?events=scAdd&f=1111&wdata={"x":12, "y":11}){kind=tracking}
Please note that the Cut Tool is available on this puzzle!
This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=188
The CASP10 organizers gave us this hint:
"Starting model GDT_TS=65. Regions 17-35 and 90-100 need special attention."
GDT_TS=65 essentially means that 65% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test
Here is the sequence logo predicted by the SAM server:
H = helix
E = sheet
C = loop (or coil)
The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.
For example, the Valines at residues 23-25 & 104 are highly predicted to be part of a helix. However, the Valines at residues 91 & 95 are predicted to be in anything.