596: CASP10 Target T0740

Summary

Name:

Status:

Closed

Created:

07/11/2012

Points:

100

Difficulty:

Advanced

Description:

The fourteenth CASP10 target is another big one: 165 residues and none of the alignment programs were able to find good templates for this target. It might be the case that this protein has no homologs. We are giving you 4 different templates (in hope that one of them is correct) for now, and will provide you with some server predictions soon. More details about this CASP target are in the puzzle comments.

Categories:

CASP, Overall, Prediction

Rank

Group

Score

Points

Anthropic Dreams

11,606

100

11,466

11,462

11,419

11,388

Rank

Player

Group

Score

Points

SimplySue 61 120

Anthropic Dreams

11,606

100

ErichVonSterich 64 162

11,583

11,573

11,564

11,564

Rank

Player

Group

Score

Points

tokens 140 1270

Anthropic Dreams

11,559

100

gdnskye 82 79

Anthropic Dreams

11,532

Hanto_FZ140E_4G 44 58

11,514

11,466

11,462

Wed, 07/11/2012 - 20:27

beta_helix 140 3540

Offline

Joined: 05/09/2008

Groups: None

Additional info about this CASP target

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=165
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Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 106 & 141 are highly predicted to be in a helix. However, the Leucine at residue 115 is predicted to be in a sheet.

NOTE THAT THIS SECONDARY STRUCTURE PREDICTION IS OBVIOUSLY NOT 100% correct, since it is impossible to have a protein with a single sheet.
Clearly there is either another strand or there are no sheets at all!
____________________________________________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1aep
http://www.pdb.org/pdb/explore/explore.do?structureId=2eh3
http://www.pdb.org/pdb/explore/explore.do?structureId=2gyq
http://www.pdb.org/pdb/explore/explore.do?structureId=1yvi