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598: CASP10 Refinement Puzzle: TR712
Status: Closed
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Groups
1 | Contenders | 13,022 | 100 | 2 | Anthropic Dreams | 13,022 | 76 | 3 | Beta Folders | 12,958 | 58 | 4 | foldeRNA | 12,915 | 43 | 5 | Void Crushers | 12,909 | 32 | 6 | Team Hungary | 12,886 | 23 | 7 | Russian team | 12,816 | 16 | 8 | L'Alliance Francophone | 12,781 | 12 | 9 | Go Science | 12,781 | 8 | 10 | Needles and Pins | 12,715 | 6 | 11 | Richard Dawkins Foundation | 12,662 | 4 | 12 | FoldIt@Netherlands | 12,654 | 3 | 13 | Newton's Cradle | 12,619 | 2 | 14 | Freedom Folders | 12,567 | 1 | 15 | 7Monkeys | 12,550 | 1 | 16 | Another Hour Another Point | 12,503 | 1 | 17 | Gargleblasters | 12,503 | 1 | 18 | Piratenpartei Deutschland | 12,418 | 1 | 19 | Natural Abilities | 12,406 | 1 | 20 | Mojo Risin' | 12,377 | 1 | 21 | SETI.Germany | 12,285 | 1 | 22 | E?????! Heureka! | 12,240 | 1 | 23 | Minions of TWIS | 12,023 | 1 | 24 | The Enlightened Flamingoes | 12,014 | 1 | 25 | Skeptics Guide to the Universe | 11,957 | 1 | Need this puzzle? Log in to download.
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This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=170
Note that the organizers gave us this hint:
"Starting model GDT_TS=92. Regions worth specific attention: 43-52, 79-92, 104-118."
GDT_TS=92 essentially means that 92% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test
Here is the sequence logo predicted by the SAM server:
H = helix
E = sheet
C = loop (or coil)
The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.
For example, the Valines at residues 18, 20, 42 & 148 are highly predicted to be part of a sheet. However, the Valine at residue 105 is predicted to be in anything.