591: Beginner CASP10 Refinement Puzzle: TR671

Summary

Name:

Status:

Closed

Created:

07/03/2012

Points:

100

Difficulty:

Beginner

Description:

This is the tenth CASP10 Refinement Target. This model was the best server prediction for target T0671, generated by the MUFOLD-Server. We've been told that only ~55% of this model matches the native, so (unlike previous CASP10 refinement puzzles) you'll need to significantly change the starting model. Luckily, this is a short target with only 88 residues. More info in the puzzle comments.

Categories:

CASP, Overall, Prediction

Rank

Group

Score

Points

Anthropic Dreams

10,163

100

10,127

10,098

10,090

10,064

Rank

Player

Group

Score

Points

Hanto_FZ140E_4G 45 61

10,199

100

10,163

10,161

ErichVonSterich 63 199

Anthropic Dreams

10,161

lamoille 23 195

Anthropic Dreams

10,161

Rank

Player

Group

Score

Points

meatexplosion 89 25

Anthropic Dreams

10,162

100

10,132

10,124

10,090

10,080

Thu, 07/05/2012 - 05:46

beta_helix 135 3196

Offline

Joined: 05/09/2008

Groups: None

More info here:

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=152

Note that the organizers gave us this hint:

"Starting model GDT_TS=55."

GDT_TS=55 essentially means that ONLY 55% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test

Secondary Structure Predictions below:

Thu, 07/05/2012 - 06:58

beta_helix 135 3196

Offline

Joined: 05/09/2008

Groups: None

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 40, 52, 73 & 86 are highly predicted to be part of a sheet. However, the Valine at residue 9 is predicted to be in anything.