New Influenza Puzzle

Thank you for participating in our new influenza puzzle: http://fold.it/portal/node/992964 .

Some players may notice that this puzzle is similar to previously posted ones, with a significant difference: two helices have been introduced to flank the designable loop. Previously, we received many interesting solutions from the Foldit community which made strong biochemical interactions with the influenza target, but unfortunately, some of these loops were ending in directions which made them difficult to superimpose onto proteins. These flanking helices constrain the designed loops so that they point in directions which improve subsequent superpositioning. However, despite these constraints, there is still a lot of room to explore, so feel free to get creative!

We will been having a Scientist Chat later today with Aaron (at 21:30 GMT) to answer any questions about this puzzle. If you are unable to make it then, please post any questions here so we can answer them during today's chat: http://fold.it/portal/node/992967 . We will post the chat transcript here: http://fold.it/portal/chats

( Posted by  beta_helix 152 13865  |  Fri, 06/15/2012 - 16:42  |  3 comments )
0
brow42's picture
User offline. Last seen 12 weeks 4 days ago. Offline
Joined: 09/19/2011
Groups: None
scaffolding

Please clarify what you mean by scaffolding (which was in the puzzle description)....are these helices supposed to fit onto the flu molecule to hold position, or fold back behind the active site loops to hold it's shape? I can imagine just folding the helices in parallel behind the loops, but this isn't going to help with positioning at all since they are just floating in space.

Joined: 05/09/2008
Groups: None
Aaron answered your question and many others during the Chat

The transcript of the Scientist Chat has been posted here:
http://fold.it/portal/node/992999

Joined: 07/11/2012
Groups: None
Sharing the game

Can we put the game on or website to share it with our readers?

Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Other Games: Mozak
Search
Only search fold.it
Recommend Foldit
User login
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons