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578: Beginner Flu Puzzle 4
Status: Closed


Name: 578: Beginner Flu Puzzle 4
Status: Closed
Created: 06/14/2012
Points: 100
Expired: 06/25/2012 - 10:00
Difficulty: Beginner
Description: We are looking for the best locations to place & design FIVE linked residues on the surface of Influenza H3 Hemagglutinin. We have placed 2 helices on either side so that it will be easier to build scaffolds for your designs. Mutate the 5 sidechains while looking for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
Categories: Design, Overall

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beta_helix's picture
User offline. Last seen 3 hours 24 min ago. Offline
Joined: 05/09/2008
Groups: None
Please read the blogpost about this puzzle:


NOTE: This puzzle is up for over 9 days due to the particularly heavily load of CASP10 puzzles this week.

Joined: 12/01/2011
Groups: Go Science
Error message

I am getting an error message when i try to open 578
"Unrecognized setup options specified: replonly"
Win 7 - 64

dsn's picture
User offline. Last seen 9 years 31 weeks ago. Offline
Joined: 09/24/2011
Groups: None
Error message

I am also getting an error message as shown above "Unrecognized setup options...", when trying to open 578.

Joined: 09/20/2011
Groups: None
Ditto on the error... :(

Ditto on the error... :(

brow42's picture
User offline. Last seen 1 year 36 weeks ago. Offline
Joined: 09/19/2011
Groups: None

This puzzle can only be played in the developer preview. Instructions for switching to dev prev are in the FAQ. However, this puzzle being posted means that either the main client is going to get an update Real Soon, or this puzzle is going to get cancelled (again.)

beta_helix's picture
User offline. Last seen 3 hours 24 min ago. Offline
Joined: 05/09/2008
Groups: None
I am very sorry about this

This was my mistake, the new update resolves this:

I have extended the puzzle deadline by a few hours to make up for this.
My apologies again and thank you for your patience!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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