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555: Symmetric Beta Core Design Puzzle 1
Status: Closed

Summary

Name: 555: Symmetric Beta Core Design Puzzle 1
Status: Closed
Created: 05/09/2012
Points: 100
Expired: 05/17/2012 - 08:00
Difficulty: Intermediate
Description: The ...WXCXW... motif adopts a remarkably stable homodimer structure. In fact, it's so tiny, it is difficult to use as a building block for bioengineering; it needs to be larger but retain rigidity. Otherwise anything goes: beta sheets, alpha helix docking, rigid loops, you name it. We've given you 20 extra residues to play with. See what you can do! (Hint: select some residues, set secondary structure to sheet or helix, and hit Rebuild for some quick helices or sheets)
Categories: Design, Overall, Symmetry

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RankGroupScorePoints
1Anthropic Dreams9,812100
2L'Alliance Francophone9,80177
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1jamiexq 58 87 Anthropic Dreams9,811100
2BitSpawn 79 2078 Anthropic Dreams9,81098
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4gmn 18 30 Anthropic Dreams9,80894
5tokens 56 33 Anthropic Dreams9,80892
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1meatexplosion 79 980 Anthropic Dreams9,812100
2Ch Garnier 79 2078 L'Alliance Francophone9,79398
3marie_s 79 2078  9,72096
4kabubi 47 40 Void Crushers9,70894
5Bletchley Park 17 34 Contenders9,70492
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Comments

Wed, 05/09/2012 - 23:45
#1
 beta_helix 79 2078
beta_helix's picture
User offline. Last seen 5 days 12 hours ago. Offline
Joined: 05/09/2008
Groups: None
More info about this puzzle in the blog:

http://fold.it/portal/node/992627

Feel free to post any questions you might have about this puzzle here, and DrLemming will answer them.

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Thu, 05/10/2012 - 00:50
#2
jamiexq 58 87
jamiexq's picture
User offline. Last seen 3 days 10 hours ago. Offline
Joined: 07/31/2011
Groups: Anthropic Dreams
Where is the move tool

Is there a move tool with this puzzle?

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Thu, 05/10/2012 - 05:38
#3
 beta_helix 79 2078
beta_helix's picture
User offline. Last seen 5 days 12 hours ago. Offline
Joined: 05/09/2008
Groups: None
No move tool for this one...

Because we want to preserve the frozen sheets and disulfide bond across the symmetric interface, we had to turn off the move tool and lock residue 7 as well.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons