555: Symmetric Beta Core Design Puzzle 1

Summary

Name:

Status:

Closed

Created:

05/09/2012

Points:

100

Difficulty:

Intermediate

Description:

The ...WXCXW... motif adopts a remarkably stable homodimer structure. In fact, it's so tiny, it is difficult to use as a building block for bioengineering; it needs to be larger but retain rigidity. Otherwise anything goes: beta sheets, alpha helix docking, rigid loops, you name it. We've given you 20 extra residues to play with. See what you can do! (Hint: select some residues, set secondary structure to sheet or helix, and hit Rebuild for some quick helices or sheets)

Categories:

Design, Overall, Symmetry

Rank

Group

Score

Points

Anthropic Dreams

9,812

100

L'Alliance Francophone

9,801

Void Crushers

9,714

Contenders

9,704

Go Science

9,693

Rank

Player

Group

Score

Points

jamiexq 13 81

Anthropic Dreams

9,811

100

9,810

9,809

9,808

9,808

Rank

Player

Group

Score

Points

meatexplosion 120 1276

Anthropic Dreams

9,812

100

Ch Garnier 24 29

L'Alliance Francophone

9,793

9,720

9,708

9,704

Wed, 05/09/2012 - 23:45

beta_helix 120 4443

Offline

Joined: 05/09/2008

Groups: None

More info about this puzzle in the blog:

http://fold.it/portal/node/992627

Feel free to post any questions you might have about this puzzle here, and DrLemming will answer them.

Thu, 05/10/2012 - 00:50

jamiexq 13 81

Offline

Joined: 07/31/2011

Groups: Anthropic Dreams

Where is the move tool

Is there a move tool with this puzzle?

Thu, 05/10/2012 - 05:38

beta_helix 120 4443

Offline

Joined: 05/09/2008

Groups: None

No move tool for this one...

Because we want to preserve the frozen sheets and disulfide bond across the symmetric interface, we had to turn off the move tool and lock residue 7 as well.