puzzle picture
547: Electron Density Puzzle 8c
Status: Closed

Summary

Name: 547: Electron Density Puzzle 8c
Status: Closed
Created: 04/20/2012
Points: 100
Expired: 04/26/2012 - 23:00
Difficulty: Advanced
Description: This is a repost of 544: Electron Density Puzzle 8b. The difference this time is that you're rewarded for fitting the density more. You're starting with an extended chain again, but you can load in your solutoins from 8b. Try to fit the protein into the density cloud to gain points, but remember that since this is real world data, sometimes you'll get more points for ignoring the density in certain areas.
Categories: Electron Density, Overall, Prediction

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Comments

marie_s's picture
User offline. Last seen 15 weeks 3 days ago. Offline
Joined: 05/18/2008
Groups: None
align to density doesnt work well

as the align tool does not work, it is difficult to be reward for fitting.
I lose points if I align
before align
http://fold.it/portal/files/chatimg/irc_33153_1335097567.png
after
http://fold.it/portal/files/chatimg/irc_33153_1335097577.png

Joined: 06/17/2010
Same there.

Align to ED always make it (score) worse. Refined alignment too.

jflat06's picture
User offline. Last seen 2 days 19 hours ago. Offline
Joined: 09/29/2010
Groups: Window Group
.

Thanks for reporting this again. We are aware of the issue. It has to do with aligning multiple chains - Foldit aligns each of them individually, trying to maximize the density fit. However, this changes the interface between the chains, resulting in a score decrease. We're considering making them align 'together'.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons