I find the blue colour in the selection interface hides a huge amount of really useful information like the colour of the side chains and the redness of a segement, so that just when you need that info ie when you are doing something with segments it all disappears. No useful info also when running a script as well to stabilise.

Also to make it worse the blue selected segs are shown as cartoon thick, and I use cartoon thin so it really makes it harder to use.

The cross hatching that appeared for a while might be a possible alternative to show what has been selected.

I know a lot of people use the selection interface only, and I would certainly use it more if it was not blue. There are other differences as well which make it a bit harder to swap between selection and advanced interfaces and they have been covered in other posts as far as I know.