puzzle picture
535: Electron Density Puzzle 8
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams9,387100
2foldeRNA9,36082
3Contenders9,34967
4Go Science9,33954
5Void Crushers9,32143
6A9709,25534
7L'Alliance Francophone9,23927
8Team Hungary9,16721
9Freedom Folders9,16217
10SETI.Germany9,15513
11FoldIt@Netherlands9,14110
12Island Dreams9,1328
13putting the eat in meat9,1186
14Russian team9,0984
15Gargleblasters9,0883
16Trailer Trash8,8782
17Another Hour Another Point8,8782
18Team Germany8,8261
19Natural Abilities8,8081
20Androids8,7801
21xkcd8,7291
22Team Tornado8,4851
23E?????! Heureka!8,4041
24Nerdfighters8,3861
25Team China8,3081


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Comments

brow42's picture
User offline. Last seen 2 years 2 weeks ago. Offline
Joined: 09/19/2011
Groups: None
Alignment score

My score drops by a lot whenever I align. Shouldn't the alignment algorithm make the alignment bonus improve when I align the protein to the ED, regardless of whether the ED is correct or not?
(Currently (8698) my OTHER score is -84 vs -157 aligned. I did a reset and wiggle, that is -80 vs -97 aligned, after fuzing -84 vs -109)(minimum threshold maximum cloud while aligning)

jflat06's picture
User offline. Last seen 2 days 14 hours ago. Offline
Joined: 09/29/2010
Groups: Window Group
.

Your intuition is correct - aligning should always increase your score.

However, the problem is that aligning isn't easy - we cant just find the perfect answer like we can for aligning a QTTN. When you press the align button, it does a bunch of complicated math to make a best guess of how to orient the protein, and then does a type of wiggle to let it settle into the density. This doesn't always get the right answer, so your score can actually drop. If you already have the protein well aligned within the density, pressing the "Refine Alignment" (I think that's what it's called...) will JUST perform the wiggle part, and will only ever increase your score.

It might make sense to have the Align button only actually replace your current alignment if the score you end up with is better. I can try this out and put it in if it works well.

auntdeen's picture
User offline. Last seen 7 years 38 weeks ago. Offline
Joined: 04/19/2009
This current ED puzzle is different...

Until this puzzle, you are right, jflat, the "Refine" has always increased score - but on this one, I'm seeing it drop by fractions instead of increase.

???

jflat06's picture
User offline. Last seen 2 days 14 hours ago. Offline
Joined: 09/29/2010
Groups: Window Group
.

Forgive me, I thought this was referring to the other button. It does seem that refining will lead to a drop in score in some cases, which should not be happening. I'll look into this.

jflat06's picture
User offline. Last seen 2 days 14 hours ago. Offline
Joined: 09/29/2010
Groups: Window Group
.

Alright, I've discovered why aligning is resulting a score decrease -

The problem is that when you press align, foldit tries to orient the protein in the way such that it gives you the most ED alignment score. Now, for a protein with a single chain, this works great. But this puzzle has two pieces, and it is trying to fit each piece into the density separately. So the relative position of the two pieces is changing when you press align. This is somewhat desirable, since you *are* matching the density better.

However, I think it is still better for align to only align, so that it can never *decrease* your score.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons