puzzle picture
522: Flu Design Puzzle 5
Status: Closed

Summary

Name: 522: Flu Design Puzzle 5
Status: Closed
Created: 02/24/2012
Points: 0
Expired: 03/02/2012 - 19:00
Difficulty: Intermediate
Description: We had to close this puzzle due to a bug. It has been reposted as Puzzle 522b where you can load in your previous 522 solutions. We apologize for this mistake and have added a couple hours to 522b's deadline.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams11,7500
2Androids11,7040
3Russian team11,6360
4Another Hour Another Point11,6290
5Contenders11,5960

Top Evolvers

RankPlayerGroupScorePoints
1krulon 60 2072 foldeRNA11,5450
2harvardman 60 303 Anthropic Dreams10,4460

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beta_helix's picture
User offline. Last seen 3 hours 14 min ago. Offline
Joined: 05/09/2008
Groups: None
Here are some sample topologies:



________________________________
More info about this Flu Puzzle:

In this Foldit puzzle the helix is frozen, but you can mutate some of the residues on it.
We want you to build & design both sections on either side of the helix.
To keep the helix from moving, we have cut both those sections on either side of the helix so you can work on them with affecting the helix.
You will notice that both ends have very strong constraints to the either side of the helix.

As discussed in the Scientist Chat (http://fold.it/portal/node/991963) we have also added minimal constraints to keep these two sections in the same general area as the above screenshots.
We have also trimmed as much of the Flu as possible and frozen all its sidechains to speed up Shake and Wiggle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons