In order to be successful on this Design Puzzle you should complete Intro Puzzle 5-2 "Movin' Along" so you can master the Move Tool.
Obviously you will also need to complete the Design Intro Puzzles.
(You can find help on all the Intro Levels here: http://foldit.wikia.com/wiki/Tutorial_Puzzles)
Read the blog for more info about these Flu puzzles:
and if you are new to Foldit, here are detailed instructions to get you started: