I usually play FoldIt on a tablet with a 1024x768 screen. It runs fine (better than my old PC), except that in some cases, I can't close certain submenu items once I open them.

Example: in the Electron Density puzzle, once I open the Electron Density submenu, I can't close it because the "X" is underneath the Rank/Score box at the top. I can open other menus (Actions, Undo, etc), but the submenu stays open until I exit and reopen FoldIt. I have tried but not been able to resize my screen to reach the closing X.

Another place this happens is the Undo > Graph Settings submenu. It's tall enough that the closing X hides under the Rank/Score box.

This also affects the View Menu (menu items above "Show Bonds (loop)" are hidden under the Rank/Score window, and I can only see the bottom line of the box above View Protein), but I can use hotkeys to change those.