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476: Unsolved Nanog Transcription Factor
Status: Closed
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Summary
| Name: |
476: Unsolved Nanog Transcription Factor |
| Status: |
Closed |
| Created: |
11/03/2011 |
| Points: |
150 |
| Difficulty: |
Intermediate |
| Description: |
Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments. |
| Categories: | Overall, Prediction |
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![](http://128.95.1.228:8000/tracking_pixel.gif?events=scAdd&f=1111&wdata={"x":12, "y":11}){kind=tracking}
You can see the Zhang Server results (where you'll find secondary structure predictions, hydrophobicity predictions, homologs used and more info) here:
http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S85502/
additional information on partial threading here:
http://fold.it/portal/node/989193#comment-9965
Please make sure to try out all 5 starting Zhang Server models, since we have no clue which one is closer to the correct native structure.