476: Unsolved Nanog Transcription Factor

Summary

Name:

Status:

Closed

Created:

11/04/2011

Points:

150

Expired:

11/14/2011 - 23:59

Difficulty:

Intermediate

Description:

Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

Categories:

Overall, Prediction

Rank

Group

Score

Points

Void Crushers

10,940

150

Contenders

10,904

130

BOINC.Italy

10,842

112

foldeRNA

10,816

L'Alliance Francophone

10,809

Rank

Player

Group

Score

Points

Madde 46 23

Void Crushers

10,940

150

Mike Cassidy 46 52

Void Crushers

10,926

149

jandersonlee 81 2386

Void Crushers

10,925

148

TheGUmmer 81 390

Void Crushers

10,922

147

spmm 81 1562

Void Crushers

10,920

145

Rank

Player

Group

Score

Points

Coskun 81 2386

11,001

150

TheGUmmer 81 390

Void Crushers

10,930

149

spmm 81 1562

Void Crushers

10,862

148

emunch 81 2386

10,848

147

marie_s 81 2386

10,848

145

Fri, 11/04/2011 - 05:17

beta_helix 81 2386

Offline

Joined: 05/09/2008

Groups: None

Additional info in the blog: http://fold.it/portal/node/991003

You can see the Zhang Server results (where you'll find secondary structure predictions, hydrophobicity predictions, homologs used and more info) here:
http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S85502/

additional information on partial threading here:

http://fold.it/portal/node/989193#comment-9965

Please make sure to try out all 5 starting Zhang Server models, since we have no clue which one is closer to the correct native structure.

Thu, 01/17/2013 - 10:20

woodenjasoon 81 2386

Offline

Joined: 01/17/2013

Groups: None

Thanks for this blog.

Thanks for this blog. Additional transcription Nanog factor mentioned info is very educative for me. I've great time learning through the Solving ways of this protein structure will help us to create solid structure.