To reduce amount of feedback threads I try to summary some of them into one.
There is list of feedbacks about CPU and GPU usage.

http://fold.it/portal/node/728230 (1)
http://fold.it/portal/node/986056 (1,3)
http://fold.it/portal/node/988114 (2)
http://fold.it/portal/node/988181 (1)
http://fold.it/portal/node/987964 (1)
http://fold.it/portal/node/988293 (4)
http://fold.it/portal/node/990133 (5)

Marked all of them as duplicate to this thread.

Major issues:
1. GUI eats one full CPU core even if we do nothing.
2. Client is not using multi cores - when minimized it is one 100% core thread + up to 15% second thread "flashing"
3. Proteins over 100 residues are almost unplayable on older machines
4. Use GPU acceleration for wiggle/shake operations.
5. Sound thread are working even if we disable all sounds/music