puzzle picture
432: De-novo Freestyle 8
Status: Closed


Name: 432: De-novo Freestyle 8
Status: Closed
Created: 06/18/2011
Points: 100
Expired: 06/25/2011 - 19:00
Difficulty: Advanced
Description: We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well.
Categories: Overall, Prediction

Top Groups

1Anthropic Dreams10,048100
4Void Crushers9,87148
5Go Science9,80837

Top Evolvers

Top Soloists

1wudoo 89 95 foldeRNA10,00298
2Mark- 171 16006 Contenders9,94195
3marie_s 171 16006  9,93893
4TheGUmmer 75 110 Void Crushers9,87191
5martinzblavy 171 16006  9,86688

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Joined: 05/09/2008
Groups: None
Please try to use these secondary structure predictions:

As requested in the feedback, http://fold.it/portal/node/989298 these secondary structure predictions have been pre-loaded into this freestyle puzzle.

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 83 is highly predicted to be part of a sheet. However, the Phenylalanine at residue 29 is equally predicted to be in a sheet or loop (so it's probably not in a helix!).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons