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420: Mini Protein Puzzle 2: Ebola Ligand
Status: Closed
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Summary
| Name: | 420: Mini Protein Puzzle 2: Ebola Ligand |
|---|---|
| Status: | Closed |
| Created: | 05/13/2011 |
| Points: | 100 |
| Expired: | 05/20/2011 - 17:00 |
| Difficulty: | Intermediate |
| Description: | Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. More details about this miniprotein in the puzzle comments. |
| Categories: | Overall, Prediction |
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This tiny domain is an independently-folding piece of a larger ubiquitin ligase protein, responsible for tagging proteins with ubiquitin (also a protein) thereby marking them for death.
This particular ubiquitin ligase is capable of binding and tagging viral proteins - but this turns out to be a bad thing, as certain viruses (like Ebola) need to have ubiquitin attached to one of their proteins in order to break free of the host cell that made them.