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420: Mini Protein Puzzle 2: Ebola Ligand
Status: Closed


Name: 420: Mini Protein Puzzle 2: Ebola Ligand
Status: Closed
Created: 05/13/2011
Points: 100
Expired: 05/20/2011 - 17:00
Difficulty: Intermediate
Description: Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. More details about this miniprotein in the puzzle comments.
Categories: Overall, Prediction

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beta_helix's picture
User offline. Last seen 2 weeks 2 days ago. Offline
Joined: 05/09/2008
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More info:

This tiny domain is an independently-folding piece of a larger ubiquitin ligase protein, responsible for tagging proteins with ubiquitin (also a protein) thereby marking them for death.

This particular ubiquitin ligase is capable of binding and tagging viral proteins - but this turns out to be a bad thing, as certain viruses (like Ebola) need to have ubiquitin attached to one of their proteins in order to break free of the host cell that made them.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons